Incidence of Hepatic Dysfunction Is Equivalent in Burn Patients Receiving Oxandrolone and Controls
Autor: | Mona C. McCullough, Ron Manning, Gillon C. Ward, Carl I. Schulman, Louis R. Pizano, Seth Goldberg, Ellie Gomez, Nicholas Namias |
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Rok vydání: | 2007 |
Předmět: |
Adult
Male medicine.medical_specialty Side effect Gastroenterology Oxandrolone Anabolic Agents Internal medicine medicine Humans In patient Aspartate Aminotransferases Retrospective Studies business.industry Incidence Incidence (epidemiology) Rehabilitation Case-control study Alanine Transaminase Retrospective cohort study Middle Aged Surgery Liver Case-Control Studies Androgens Body Composition Emergency Medicine Abnormal Liver Function Test Female Chemical and Drug Induced Liver Injury Burns business Hepatic dysfunction medicine.drug |
Zdroj: | Journal of Burn Care & Research. 28:412-420 |
ISSN: | 1559-047X |
Popis: | Oxandrolone has been shown to improve lean muscle mass in patients with burns. Hepatic dysfunction is a known side effect of treatment with oxandrolone. The purpose of this study was to examine the incidence of hepatic dysfunction in our series of burn patients receiving oxandrolone. Fourteen patients who received oxandrolone (5 mg, n = 8; 10 mg, n = 6) were identified from our prospectively collected burn database. The records of 61 control patients also were reviewed. Demographics such as age, comorbidities, and burn size were recorded. The incidence of hepatic dysfunction was determined by the presence of abnormal liver function tests. The study and control groups were similar in age and burn size. Two of the eight (25%) oxandrolone patients receiving 5 mg and four of the six (67%) oxandrolone patients receiving 10 mg had evidence of hepatic dysfunction. Twenty six of the 61 (43%) control patients had evidence of hepatic dysfunction (P = NS). There appears no significant increased incidence of hepatic dysfunction in burn patients who received oxandrolone compared to those who did not. |
Databáze: | OpenAIRE |
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