Measles Maternal Antibodies With Low Avidity Do Not Interfere With the Establishment of Robust Quantity and Quality Antibody Responses After the Primary Dose of Measles, Mumps, and Rubella Vaccine Administered at 12-Months of Age

Autor:	Susette Audet, Linda L. Yasukawa, Judy A. Beeler, Tobias R. Kollmann, Laura Gelinas, Hayley A. Gans, Stuart E. Turvey, Cathleen A. Collins, Bahaa Abu-Raya
Rok vydání:	2019
Předmět:	Measles Vaccine chemical and pharmacologic phenomena Antibodies Viral MMR vaccine Measles 03 medical and health sciences Rubella vaccine 0302 clinical medicine Humans Medicine Avidity 030212 general & internal medicine Child Mumps 030304 developmental biology 0303 health sciences biology business.industry Immunogenicity Infant General Medicine medicine.disease Infectious Diseases Immunization Antibody Formation Pediatrics Perinatology and Child Health Immunology biology.protein Brief Reports Measles vaccine Antibody business Measles-Mumps-Rubella Vaccine medicine.drug
Zdroj:	J Pediatric Infect Dis Soc
ISSN:	2048-7207
DOI:	10.1093/jpids/piz074
Popis:	In this study, we illustrate, for the first time, that preexisting low-avidity neutralizing measles maternal antibodies do not interfere with the development of high concentrations of high-avidity measles antibodies in children immunized at age 12 months. This suggests that the quality of measles maternal antibodies, rather than the quantity, impacts immunogenicity of primary measles immunization.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c69dceece3ca4e7f3ced6cf1983e3978 https://doi.org/10.1093/jpids/piz074 Zobrazit plný text záznamu