The evidence for pharmacist care in outpatients with heart failure: a systematic review and meta-analysis
| Autor: | Schumacher, Pia M, Becker, Nicolas, Tsuyuki, Ross T, Griese-Mammen, Nina, Koshman, Sheri L, McDonald, Michael A, Bouvy, Marcel, Rutten, Frans H, Laufs, Ulrich, Böhm, Michael, Schulz, Martin, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology |
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| Přispěvatelé: | Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Pharmacist Heart failure Disease Pharmacists law.invention Medication Adherence Quality of life Randomized controlled trial law Original Research Articles Outpatients Pharmacist care medicine Diseases of the circulatory (Cardiovascular) system Humans Original Research Article business.industry Odds ratio 500 Naturwissenschaften und Mathematik::570 Biowissenschaften Biologie::570 Biowissenschaften Biologie medicine.disease Hospitalization Meta-analysis Strictly standardized mean difference RC666-701 Emergency medicine Meta‐analysis Systematic review business Cardiology and Cardiovascular Medicine |
| Zdroj: | ESC heart failure, 8(5), 3566. The Heart Failure Association of the European Society of Cardiology ESC Heart Failure ESC Heart Failure, Vol 8, Iss 5, Pp 3566-3576 (2021) |
| ISSN: | 2055-5822 |
| Popis: | Aims Patients with heart failure (HF) have poor outcomes, including poor quality of life, and high morbidity and mortality. In addition, they have a high medication burden due to the multiple drug therapies now recommended by guidelines. Previous reviews, including studies in hospital settings, provided evidence that pharmacist care improves outcomes in patients with HF. Because most HF is managed outside of hospitals, we aimed to synthesize the evidence for pharmacist care in outpatients with HF. Methods and results We conducted a systematic literature search in PubMed of randomized controlled trials (RCTs) and integrated the evidence on patient outcomes in a meta‐analysis. We found 24 RCTs performed in 10 countries, including 8029 patients. The data revealed consistent improvements in medication adherence (independent of the measuring instrument) and knowledge, physical function, and disease and medication management. Sixteen RCTs were included in meta‐analyses. Differences in all‐cause mortality (odds ratio (OR) = 0.97 [95% CI, 0.84–1.12], Q‐statistic, P = 0.49, I 2 = 0%), all‐cause hospitalizations (OR = 0.86 [0.73–1.03], Q‐statistic, P = 0.01, I 2 = 45.5%), and HF hospitalizations (OR = 0.89 [0.77–1.02], Q‐statistic, P = 0.11, I 2 = 0%) were not statistically significant. We also observed an improvement in the standardized mean difference for generic quality of life of 0.75 ([0.49–1.01], P |
| Databáze: | OpenAIRE |
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