Expression pattern of matrix metalloproteinases-2 and -9 and their tissue inhibitors in patients with chronic inflammatory demyelinating polyneuropathy
| Autor: | Cristina Tassorelli, Enrico Alfonsi, Matteo Gastaldi, Maria Montana, Gregorio Caimi, Vincenzo Di Stefano, Filippo Brighina, Massimiliano Todisco, Rosalia Lo Presti, Brigida Fierro, Giuseppe Cosentino, Andrea Cortese |
|---|---|
| Přispěvatelé: | Cosentino G., Di Stefano V., Lo Presti R., Montana M., Todisco M., Gastaldi M., Cortese A., Alfonsi E., Tassorelli C., Fierro B., Caimi G., Brighina F. |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Neurology Chronic inflammatory demyelinating polyneuropathy CIDP Dermatology Matrix metalloproteinase Gastroenterology Tissue inhibitor of matrix metalloproteinase 03 medical and health sciences 0302 clinical medicine Immune system Expression pattern Downregulation and upregulation Internal medicine Endopeptidases medicine TIMP Humans In patient 030212 general & internal medicine MMP business.industry General Medicine medicine.disease Matrix Metalloproteinases Pathophysiology Psychiatry and Mental health Matrix Metalloproteinase 9 Polyradiculoneuropathy Chronic Inflammatory Demyelinating Matrix Metalloproteinase 2 Settore MED/26 - Neurologia Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Neurological Sciences. 42:4297-4300 |
| ISSN: | 1590-3478 1590-1874 |
| Popis: | Background: Matrix metalloproteinases (MMPs) are a heterogeneous family of endopeptidases that play a role in many physiological functions, including the immune response. An imbalance between the activity of MMPs and their physiological tissue inhibitors (TIMPs) has been proposed in the pathophysiology of different autoimmune disorders. We aimed to assess the plasmatic levels of MMP-2, MMP-9, and their inhibitors TIMP-1 and -2 in patients with chronic inflammatory demyelinating polyneuropathy (CIDP). Subjects and methods: Twenty patients with CIDP and 20 age- and sex-matched healthy controls were enrolled. Plasma concentrations of MMP-2, MMP-9, TIMP-1, and TIMP-2 were determined by the enzyme-linked immunosorbent assay. Results: CIDP subjects had higher MMP-9 concentrations along with TIMP-1 downregulation when compared to controls, with the consequent increase in the MMP-9/TIMP-1 ratio (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|