Variation in the modality of a yeast signaling pathway is mediated by a single regulator

Autor: Michael Springer, Julius Palme, Jue Wang
Rok vydání: 2021
Předmět:
medicine.medical_specialty
Saccharomyces cerevisiae Proteins
QH301-705.5
Science
Systems biology
Saccharomyces cerevisiae
Regulator
S. cerevisiae
Biology
General Biochemistry
Genetics and Molecular Biology
Physical medicine and rehabilitation
Gene Expression Regulation
Fungal
Concussion
Gene expression
Genetic variation
medicine
Injury risk
Risk factor
Biology (General)
Hamstring injury
Regulation of gene expression
General Immunology and Microbiology
business.industry
General Neuroscience
Galactose
Genetic Variation
phenotypic variation
General Medicine
nutrient signaling
medicine.disease
biology.organism_classification
ACL injury
Muscular injury
Cell biology
Increased risk
Medicine
Genetic Fitness
Adaptation
Signal transduction
business
gene regulation
Tertiary Prevention
Signal Transduction
Transcription Factors
Research Article
Computational and Systems Biology
Zdroj: eLife
eLife, Vol 10 (2021)
ISSN: 2050-084X
DOI: 10.7554/elife.69974
Popis: Background Previous injury is a strong risk factor for recurrent lower limb injury in athletic populations, yet the association between previous injury and a subsequent injury different in nature or location is rarely considered. Objective To systematically review data on the risk of sustaining a subsequent lower limb injury different in nature or location following a previous injury. Methods Eight medical databases were searched. Studies were eligible if they reported lower limb injury occurrence following any injury of a different anatomical site and/or of a different nature, assessed injury risk, contained athletic human participants and were written in English. Two reviewers independently applied the eligibility criteria and performed the risk of bias assessment. Meta-analysis was conducted using a random effects model. Results Twelve studies satisfied the eligibility criteria. Previous history of an ACL injury was associated with an increased risk of subsequent hamstring injury (three studies, RR=2.25, 95% CI 1.34 to 3.76), but a history of chronic groin injury was not associated with subsequent hamstring injury (three studies, RR=1.14, 95% CI 0.29 to 4.51). Previous lower limb muscular injury was associated with an increased risk of sustaining a lower limb muscular injury at a different site. A history of concussion and a variety of joint injuries were associated with an increased subsequent lower limb injury risk. Conclusions The fact that previous injury of any type may increase the risk for a range of lower limb subsequent injuries must be considered in the development of future tertiary prevention programmes. Systematic review registration number CRD42016039904 (PROSPERO).
Databáze: OpenAIRE
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