Sensitivity and specificity of fine needle aspiration for the diagnosis of mediastinal lesions
| Autor: | Tamara Giorgadze, Mohamed K. Kamel, Jeffrey L. Port, Alan Marcus, Nasser K. Altorki, Navneet Narula, Brendon M. Stiles, Andre L. Moreira, June Koizumi |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Pathology Thymoma Adolescent Biopsy Fine-Needle Mediastinal Neoplasms Sensitivity and Specificity Pathology and Forensic Medicine Metastatic carcinoma Surgical pathology Young Adult 03 medical and health sciences 0302 clinical medicine Paraganglioma Biopsy medicine Humans Child Thymic carcinoma Aged Aged 80 and over medicine.diagnostic_test business.industry Mediastinum General Medicine Middle Aged Thoracic Surgical Procedures medicine.disease body regions 030104 developmental biology medicine.anatomical_structure Fine-needle aspiration 030220 oncology & carcinogenesis Female Radiology Triage business |
| Zdroj: | Annals of Diagnostic Pathology. 39:69-73 |
| ISSN: | 1092-9134 |
| DOI: | 10.1016/j.anndiagpath.2019.02.011 |
| Popis: | Fine needle aspiration cytology (FNAC) of mediastinal masses allows for rapid on-site evaluation and the triaging of material for ancillary studies. However, surgical pathology is often considered to be the gold standard for diagnosis. This study examines the sensitivity and specificity of FNAC compared to a concurrent or subsequent surgical pathology specimen in 77 mediastinal lesions. The overall sensitivity for mediastinal mass FNAC was 78% and the overall specificity was 98%. For individual categories the sensitivity and specificity of FNAC was respectively as follows: inflammatory/infectious (33%, 99%), metastatic carcinoma (93%, 100%), lymphoma (84%, 97%), cysts (25%, 100%), soft tissue tumors (100%, 100%), paraganglioma (50%, 100%), germ cell tumor (100%, 99%), thymoma (87%, 94%), thymic carcinoma (60%, 100%), benign thymus (0%, 100%), and indeterminate (100%, 90%). For different locations within the mediastinum the sensitivity and specificity of FNAC was respectively as follows: anterosuperior mediastinum (80%, 98%), posterior mediastinum (33%, 95%), middle mediastinum (100%, 100%), and mediastinum, NOS (79%, 99%). Thus, mediastinal FNAC is fairly sensitive, very specific, and is a valuable technique in the diagnosis of mediastinal masses. |
| Databáze: | OpenAIRE |
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