Cardiomyoplasty benefits in experimental myocardial dysfunction
| Autor: | Antonio Carlos P. Chagas, E.E. Adolfo Leirner M.D., Protasio Lemos Da Luz, Paulo M. Pèo-Fernandes, Adib D. Jatene, Gustavo P. Camarano, Luiz Felipe P. Moreira, Noedir A.G. Stolf |
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| Rok vydání: | 1989 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Cardiac output medicine.medical_treatment Cardiomyopathy Electric Stimulation Therapy Surgical Flaps Dogs Internal medicine medicine Animals Assisted Circulation Pulmonary wedge pressure Ejection fraction business.industry Muscles Hemodynamics Dilated cardiomyopathy medicine.disease Myocardial Contraction medicine.anatomical_structure Ventricle Echocardiography Anesthesia Heart failure Cardiology Surgery Cardiology and Cardiovascular Medicine business Cardiomyopathies Cardiomyoplasty |
| Zdroj: | Journal of cardiac surgery. 4(2) |
| ISSN: | 0886-0440 |
| Popis: | Beneficial effects of cardiomyoplasty have been documented and the use of this technique in the treatment of dilated cardiomyopathy have been suggested. This study was undertaken to evaluate the effectiveness of stimulated preconditioned latissimus dorsi muscle flaps wrapped around the heart in order to restore ventricular contractility in six adult mongrel dogs with induced myocardial dysfunction by administration of beta blockers and volume loading. Hemodynamic and two-dimensional echocardiographic evaluation were performed 1 week after the surgical procedure and immediately after heart failure induction. With synchronous pulse train electrical stimulation, cardiac output increased from 1.46 +/- 0.13 (+/- SD) to 2.01 +/- 0.16 L/min (p less than 0.01), pulmonary wedge pressure decreased from 15.5 +/- 1.2 to 11.3 +/- 1.6 mmHg (p less than 0.01) and left ventricular end-diastolic pressure from 18.3 +/- 2.4 to 13.5 +/- 1.4 mmHg (p less than 0.04). Echo derived left ventricular ejection fraction increased from 39.3 +/- 2.4 to 59.6 +/- 2.9% (p less than 0.01) and segmental wall shortening from 15.4 +/- 1.2 to 26.3 +/- 1.7% (p less than 0.01), inclusive when the muscle flap was wrapped only around the left ventricle. In conclusion, this study suggests that cardiomyoplasty may be an alternative method of treatment for irreversible cardiomyopathy, including in patients with a great cardiac enlargement in which muscle flap may only be wrapped partially around the heart. |
| Databáze: | OpenAIRE |
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