Molecular recognition studies on naphthyridine derivatives
Autor: | Dolores Santa María, Rosa M. Claramunt, José Elguero, José Carlos Iglesias-Sánchez |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2010 |
Předmět: |
Magnetic Resonance Spectroscopy
Stereochemistry Pharmaceutical Science naphthyridine Article Analytical Chemistry lcsh:QD241-441 chemistry.chemical_compound Molecular recognition lcsh:Organic chemistry Biotin biotin Amide acridine Drug Discovery Molecule Physical and Theoretical Chemistry Naphthyridines Receptor host-guest Binding Sites Chemistry Hydrogen bond Organic Chemistry Hydrogen Bonding NMR titrations Chemistry (miscellaneous) Acridine Molecular Medicine Titration |
Zdroj: | Molecules Volume 15 Issue 3 Pages 1213-1222 Molecules, Vol 15, Iss 3, Pp 1213-1222 (2010) Digital.CSIC. Repositorio Institucional del CSIC instname |
Popis: | The association constants Kb of three hosts I-III designed to have both enhanced hydrogen bonding donor strength and conformational preorganization with biotin analogues 1-5 are reported. 1H-NMR titrations under two different concentration conditions have been employed to determine the association constants Kb. A statistical analysis using a presence absence matrix has been applied to calculate the different contributions. Hydrogen bond interactions make naphthyridine derivatives II and III potent binders and effective receptors for (+)-biotin methyl ester (1), due to the complex stabilization by additional hydrogen bonds. © 2010 by the authors. |
Databáze: | OpenAIRE |
Externí odkaz: |