Molecular recognition studies on naphthyridine derivatives

Autor: Dolores Santa María, Rosa M. Claramunt, José Elguero, José Carlos Iglesias-Sánchez
Jazyk: angličtina
Rok vydání: 2010
Předmět:
Zdroj: Molecules
Volume 15
Issue 3
Pages 1213-1222
Molecules, Vol 15, Iss 3, Pp 1213-1222 (2010)
Digital.CSIC. Repositorio Institucional del CSIC
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Popis: The association constants Kb of three hosts I-III designed to have both enhanced hydrogen bonding donor strength and conformational preorganization with biotin analogues 1-5 are reported. 1H-NMR titrations under two different concentration conditions have been employed to determine the association constants Kb. A statistical analysis using a presence absence matrix has been applied to calculate the different contributions. Hydrogen bond interactions make naphthyridine derivatives II and III potent binders and effective receptors for (+)-biotin methyl ester (1), due to the complex stabilization by additional hydrogen bonds. © 2010 by the authors.
Databáze: OpenAIRE