Symptomatic Primary Selective Immunoglobulin M Deficiency with Nonprotective Pneumococcal Titers Responsive to Subcutaneous Immunoglobulin Treatment
| Autor: | Mark C. Glaum, Jennifer E. Fergeson, Richard F. Lockey, Shiven S. Patel |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine Injections Subcutaneous Immunology Immunoglobulins Subcutaneous immunoglobulin medicine.disease_cause Malignancy Asymptomatic Antibodies Pneumococcal Infections Autoimmunity 03 medical and health sciences 0302 clinical medicine Agammaglobulinemia Humans Immunology and Allergy Medicine business.industry Immunization Passive General Medicine medicine.disease Pneumococcal polysaccharide vaccine Titer Treatment Outcome 030104 developmental biology Antibody response Immunoglobulin M 030228 respiratory system Selective immunoglobulin M deficiency medicine.symptom business |
| Zdroj: | International Archives of Allergy and Immunology. 170:138-140 |
| ISSN: | 1423-0097 1018-2438 |
| DOI: | 10.1159/000447693 |
| Popis: | Selective immunoglobulin M deficiency (SIgMD) is a rare disorder with varying clinical features. The prevalence of SIgMD is 0.03-3%. Patients may be asymptomatic or else present with recurrent infection, autoimmunity, atopic disease and/or malignancy. About 50% of patients with symptomatic SIgMD also have impaired antibody responses to the pneumococcal polysaccharide vaccine. We report on an adult who presented with symptomatic SIgMD with impaired pneumococcal polysaccharide antibody responses and lymphopenia, who experienced a significant clinical improvement in the frequency of infections after subcutaneous immunoglobulin replacement therapy. |
| Databáze: | OpenAIRE |
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