Dendritic cell sarcoma: A pooled analysis including 462 cases with presentation of our case series
| Autor: | Nukhet Tuzuner, Caner Saygin, Didem Uzunaslan, Mustafa Şenocak, Mustafa Ozguroglu |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Histiocytic Disorders Malignant Male medicine.medical_specialty Pathology Fibroblastic Reticular Cell Tumor medicine.medical_treatment Internal medicine medicine Humans Chemotherapy Hematology business.industry Sarcoma Dendritic Cells Dendritic cell Middle Aged Prognosis medicine.disease Tumor Burden Treatment Outcome Coagulative necrosis Pooled analysis Oncology Follicular dendritic cell sarcoma Interdigitating dendritic cell sarcoma Female business |
| Zdroj: | Critical Reviews in Oncology/Hematology. 88:253-271 |
| ISSN: | 1040-8428 |
| DOI: | 10.1016/j.critrevonc.2013.05.006 |
| Popis: | Dendritic cell tumors are extremely rare and current knowledge on these tumors is limited. The characteristics of three dendritic cell sarcoma subtypes and their optimal treatment approaches are not fully clarified. We aimed to make a systematic review of the literature and enrich the current data with five new cases. Pooled analysis of 462 reported cases revealed that the tumor had no age, gender or racial predilection. Our analysis suggests that the young age, advanced stage, intraabdominal involvement and unfavorable histological features (i.e. large tumor size, absence of lymphoplasmacytic infiltration, coagulative necrosis, high mitotic count) may predict poor prognosis. Subtypes of this tumor have different clinical behaviors with interdigitating dendritic cell sarcoma being the most aggressive form. In general, surgery is the most effective treatment modality and adjuvant radiotherapy has no significant effect on overall survival of patients. The role of chemotherapy for the management of advanced disease is controversial. |
| Databáze: | OpenAIRE |
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