Discovery and Structure-Based Optimization of Novel Atg4B Inhibitors for the Treatment of Castration-Resistant Prostate Cancer

Autor:	Yudai Kudo, Satoshi Endo, Mei Fujita, Atsumi Ota, Yuji O. Kamatari, Yoshimasa Tanaka, Takeshi Ishikawa, Hayato Ikeda, Takuya Okada, Naoki Toyooka, Naohiro Fujimoto, Toshiyuki Matsunaga, Akira Ikari
Rok vydání:	2022
Předmět:	Male Cysteine Endopeptidases Prostatic Neoplasms Castration-Resistant Cell Line Tumor Drug Discovery Autophagy Molecular Medicine Autophagy-Related Proteins Humans Apoptosis
Zdroj:	Journal of medicinal chemistry. 65(6)
ISSN:	1520-4804
Popis:	Autophagy inhibition is an attractive target for cancer therapy. In this study, we discovered inhibitors of Atg4B essential for autophagosome formation and evaluated their potential as therapeutics for prostate cancer. Seventeen compounds were identified as candidates after
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6928dede6aeb19aac87666cc6267a5d https://pubmed.ncbi.nlm.nih.gov/35622956 Zobrazit plný text záznamu