Neuromyelitis Optica Treatment
| Autor: | Alberto Alain Gabbai, Daniel May Oliveira, Nilton Amorin de Souza, Denis Bernardi Bichuetti, Enedina Maria Lobato de Oliveira |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Pediatrics Cyclophosphamide Azathioprine Central nervous system disease Arts and Humanities (miscellaneous) Prednisone medicine Humans Age of Onset Adverse effect Retrospective Studies Neuromyelitis optica business.industry Multiple sclerosis Neuromyelitis Optica Middle Aged medicine.disease Surgery Treatment Outcome Disease Progression Female Methotrexate Neurology (clinical) business Brazil Immunosuppressive Agents medicine.drug |
| Zdroj: | Archives of Neurology. 67 |
| ISSN: | 0003-9942 |
| Popis: | Objective To analyze treatment response in Brazilian patients with neuromyelitis optica. Design Retrospective review. Setting Neuroimmunology Clinic of the Federal University of Sao Paulo, Sao Paulo, Brazil. Patients Thirty-six patients with relapsing-remitting optic-spinal disease; long, extending spinal cord lesions; and brain magnetic resonance images not meeting Barkhof criteria for multiple sclerosis, thus fulfilling the 1999 and 2006 criteria for neuromyelitis optica. Patients were followed up from 1994 to 2007. Main Outcome Measures Relapses and accumulation of disability. Results Mean follow-up time was 47.2 months and mean age at onset was 32.3 years. Sixty-four treatments were implemented in 36 patients, which included interferon beta, methotrexate, cyclophosphamide, prednisone, and azathioprine solely or plus prednisone. Patients who were treated with azathioprine or azathioprine with prednisone had a reduction in the occurrence of relapses and Expanded Disability Severity Scale score stabilization, as opposed to patients who received other treatments. Of the 4 patients who died, only 1 had received azathioprine treatment. Conclusion Azathioprine as monotherapy or with prednisone seems to have reduced the relapse frequency and halted disability progression in the majority of patients treated, with minor and manageable adverse effects. |
| Databáze: | OpenAIRE |
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