Stress, inflammation and hippocampal subfields in depression: A 7 tesla MRI study
| Autor: | Phil J. Cowen, Jair C. Soares, Beata R. Godlewska, Sudhakar Selvaraj, Jonika Tannous, Vaishali Tirumalaraju |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Oncology
medicine.medical_specialty Significant group Inflammation Hippocampal formation behavioral disciplines and activities Hippocampus Article lcsh:RC321-571 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Internal medicine mental disorders medicine 7 tesla mri Humans lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Biological Psychiatry Depression (differential diagnoses) Depressive Disorder Major business.industry Depression Interleukin Diagnostic markers medicine.disease Magnetic Resonance Imaging 030227 psychiatry 3. Good health Psychiatry and Mental health Cohort Major depressive disorder medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Translational Psychiatry Translational Psychiatry, Vol 10, Iss 1, Pp 1-7 (2020) |
| Popis: | Experiencing stressful events throughout one’s life, particularly childhood trauma, increases the likelihood of being diagnosed with Major Depressive Disorder (MDD). Raised levels of cortisol, and markers of inflammation such as Interleukin (IL-6) and C-reactive protein (CRP), have been linked to both early life stress and MDD. We aimed to explore the biological stress signatures of early stress and MDD on hippocampal sub regional volumes using 7 Tesla MRI imaging. A cohort of 71 MDD patients was compared against 46 age and sex-matched healthy volunteers. MDD subjects had higher averages of IL-6 and CRP levels. These differences were significant for IL-6 levels and trended for CRP. There were no significant group differences in any of the hippocampal subfields or global hippocampal volumes; further, there were no hippocampal subfield differences between MDD subjects with high levels of our biological stress measures and MDDs with normal levels. |
| Databáze: | OpenAIRE |
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