Sarcopenia Definition: The Position Statements of the Sarcopenia Definition and Outcomes Consortium

Autor: Karol M. Pencina, Ralph B. DʼAgostino, Greg Gorsicki, Brian C. Clark, Todd M. Manini, Peggy M. Cawthon, Roger A. Fielding, Jack M. Guralnik, Jane A. Cauley, Jay Magaziner, Jean Woo, Hidenori Arai, Thomas G. Travison, Quian Li Xue, Douglas P. Kiel, Daniel Rooks, Sheena Patel, Rosaly Correa-de-Araujo, Laura A. Schaap, Suzette L. Pereira, Ellen F. Binder, Todd T. Brown, Denise Orwig, Francesco Landi, Cyrus Cooper, Linda J. Woodhouse, Anne B. Newman, Michelle Shardell, Shalender Bhasin
Přispěvatelé: Nutrition and Health, APH - Aging & Later Life, APH - Health Behaviors & Chronic Diseases, AMS - Musculoskeletal Health
Rok vydání: 2020
Předmět:
Zdroj: Bhasin, S, Travison, T G, Manini, T M, Patel, S, Pencina, K M, Fielding, R A, Magaziner, J M, Newman, A B, Kiel, D P, Cooper, C, Guralnik, J M, Cauley, J A, Arai, H, Clark, B C, Landi, F, Schaap, L A, Pereira, S L, Rooks, D, Woo, J, Woodhouse, L J, Binder, E, Brown, T, Shardell, M, Xue, Q L, DʼAgostino, R B, Orwig, D, Gorsicki, G, Correa-De-Araujo, R & Cawthon, P M 2020, ' Sarcopenia Definition: The Position Statements of the Sarcopenia Definition and Outcomes Consortium ', Journal of the American Geriatrics Society, vol. 68, no. 7, pp. 1410-1418 . https://doi.org/10.1111/jgs.16372
Journal of the American Geriatrics Society, 68(7), 1410-1418. Wiley-Blackwell
ISSN: 1532-5415
0002-8614
DOI: 10.1111/jgs.16372
Popis: Objectives To develop an evidence-based definition of sarcopenia that can facilitate identification of older adults at risk for clinically relevant outcomes (eg, self-reported mobility limitation, falls, fractures, and mortality), the Sarcopenia Definition and Outcomes Consortium (SDOC) crafted a set of position statements informed by a literature review and SDOC's analyses of eight epidemiologic studies, six randomized clinical trials, four cohort studies of special populations, and two nationally representative population-based studies. Methods Thirteen position statements related to the putative components of a sarcopenia definition, informed by the SDOC analyses and literature synthesis, were reviewed by an independent international expert panel (panel) iteratively and voted on by the panel during the Sarcopenia Position Statement Conference. Four position statements related to grip strength, three to lean mass derived from dual-energy x-ray absorptiometry (DXA), and four to gait speed; two were summary statements. Results The SDOC analyses identified grip strength, either absolute or scaled to measures of body size, as an important discriminator of slowness. Both low grip strength and low usual gait speed independently predicted falls, self-reported mobility limitation, hip fractures, and mortality in community-dwelling older adults. Lean mass measured by DXA was not associated with incident adverse health-related outcomes in community-dwelling older adults with or without adjustment for body size. Conclusion The panel agreed that both weakness defined by low grip strength and slowness defined by low usual gait speed should be included in the definition of sarcopenia. These position statements offer a rational basis for an evidence-based definition of sarcopenia. The analyses that informed these position statements are summarized in this article and discussed in accompanying articles in this issue of the journal. J Am Geriatr Soc 68:1410-1418, 2020.
Databáze: OpenAIRE
Externí odkaz: