Biophysical properties, efficacy, and lesion characteristics of a new linear cryoablation catheter in a canine model
| Autor: | Maryam E. Rettmann, Songyun Wang, Kristi H. Monahan, H. Immo Lehmann, Atsushi Suzuki, Douglas L. Packer, Kay D. Parker |
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| Rok vydání: | 2020 |
| Předmět: |
Ablation Techniques
Tachycardia Ectopic Atrial medicine.medical_treatment 030204 cardiovascular system & hematology Cryosurgery Pulmonary vein Lesion Electrocardiography 03 medical and health sciences Dogs 0302 clinical medicine Heart Conduction System Physiology (medical) medicine Animals 030212 general & internal medicine Atrial tachycardia business.industry Atrial fibrillation Cryoablation medicine.disease Disease Models Animal Catheter Pulmonary Veins medicine.symptom Cardiology and Cardiovascular Medicine business Nuclear medicine Canine model Atrial flutter |
| Zdroj: | Heart Rhythm. 17:1967-1975 |
| ISSN: | 1547-5271 |
| DOI: | 10.1016/j.hrthm.2020.05.028 |
| Popis: | Background The cryoballoon (CB) catheter is an established tool for pulmonary vein isolation (PVI), but its use is limited for that purpose. Objective The purpose of this study was to investigate the biophysical properties of a newly developed linear cryoablation catheter for creation of linear ablation lesions in an in vivo model. Methods Twenty-nine dogs (14 acutely ablated, 15 chronically followed) underwent cryoablation using the linear cryoablation catheter. Regions of interest included the cavotricuspid isthmus (CTI), mitral isthmus (MI), left atrial (LA) roof, and LA posterior wall in an acute study. Cryoablations for CTI and MI were performed in 14 atrial fibrillation animals after PVI and followed over 1 month in the chronic study. Tissue temperature during cryoablation was monitored using implanted thermocouples in the regions of interest. Gross and microscopic pathologic characteristics of the lesions were assessed. Results In acute animals, lesion length (transmurality) was CTI 34 ± 4 mm (89% ± 11%); MI 29 ± 4 mm (90% ± 13%); LA roof 19 ± 3 mm (90% ± 8%); and LA posterior wall 19 ± 2 mm (81% ± 13%), with 1 or 2 freezes. Chronic bidirectional block was achieved in 13 of 14 CTI (93%) and 10 of 14 MI (71%) ablations after 1-month follow-up and was consistent with lesion continuity and transmurality upon pathology. The lowest tissue temperature correlated well with the closest distance to the linear cryocatheter (r = 0.688; P Conclusion This linear cryocatheter created continuous and transmural linear lesions with “single-shot” cryoenergy application and has the potential for clinical use in the setting of various arrhythmias. |
| Databáze: | OpenAIRE |
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