Exaggerated Cardiac Contractile Response to Hypoxia in Adults Born Preterm
| Autor: | Naomi C. Chesler, Marlowe W. Eldridge, Kara N. Goss, Philip A. Corrado, Christopher J. François, Oliver Wieben, Gregory P. Barton |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Cardiac function curve
medicine.medical_specialty Clinical Sciences lcsh:Medicine 030204 cardiovascular system & hematology Cardiovascular Low Birth Weight and Health of the Newborn Article Physiologic stressor 03 medical and health sciences 0302 clinical medicine Acute hypoxia Cardiac magnetic resonance imaging Clinical Research Preterm Internal medicine Infant Mortality contractile response medicine 2.1 Biological and endogenous factors 030212 general & internal medicine Aetiology Pediatric Ejection fraction medicine.diagnostic_test business.industry hypoxia Contractile response prematurity lcsh:R General Medicine Hypoxia (medical) Perinatal Period - Conditions Originating in Perinatal Period Heart Disease Good Health and Well Being Cardiology cardiovascular system Gestation Biomedical Imaging medicine.symptom cardiac function business |
| Zdroj: | Journal of Clinical Medicine, Vol 10, Iss 1166, p 1166 (2021) Journal of Clinical Medicine Volume 10 Issue 6 Journal of clinical medicine, vol 10, iss 6 |
| ISSN: | 2077-0383 |
| Popis: | Individuals born prematurely have smaller hearts, cardiac limitations to exercise, and increased overall cardiometabolic risk. The cardiac effects of acute hypoxia exposure as another physiologic stressor remain under explored. The purpose of this study was to determine the effects of hypoxia on ventricular function in adults born preterm. Adults born moderately to extremely preterm (≤32 weeks gestation or < 1500 g, N = 32) and born at term (N = 18) underwent cardiac magnetic resonance imaging under normoxic (21% O2) and hypoxic (12% O2) conditions to assess cardiovascular function. In normoxia, cardiac function parameters were similar between groups. During hypoxia, the right ventricular (RV) contractile response was significantly greater in participants born premature, demonstrated by greater increases in RV ejection fraction (EF) (p = 0.002), ventricular-vascular coupling (VVC) (p = 0.004), and strain (p < 0.0001) measures compared to term-born participants, respectively. Left ventricular contractile reserve was similar to term-born participants. Adults born preterm exhibit an exaggerated contractile response to acute hypoxia, particularly in the RV. This suggests that adults born preterm may have contractile reserve, despite the lack of volume reserve identified in previous exercise studies. However, this exaggerated and hyper-adapted response may also increase their risk for late RV failure. |
| Databáze: | OpenAIRE |
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