Combining prostate health index and multiparametric magnetic resonance imaging in estimating the histological diameter of prostate cancer
Autor: | Tzung-Ruei Li, Chi-Ping Huang, Chao-Hsiang Chang, Chi-Rei Yang, Wen-Chin Huang, Po Fan Hsieh, Hsi Chin Wu, Han Chang, Chin-Chung Yeh, Wei-Ching Lin |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Male
Urology medicine.medical_treatment Biopsy Safety margin Prostate cancer Health index Prostate Multiparametric magnetic resonance imaging Prostate health index medicine Humans Multiparametric Magnetic Resonance Imaging Aged Retrospective Studies Tumor size business.industry Prostatectomy Research Tumor diameter Prostatic Neoplasms General Medicine Middle Aged Prostate-Specific Antigen medicine.disease Diseases of the genitourinary system. Urology medicine.anatomical_structure Reproductive Medicine Radiological weapon Feasibility Studies RC870-923 Nuclear medicine business |
Zdroj: | BMC Urology BMC Urology, Vol 21, Iss 1, Pp 1-8 (2021) |
ISSN: | 1471-2490 |
Popis: | Background Although multiparametric magnetic resonance imaging (mpMRI) is widely used to assess the volume of prostate cancer, it often underestimates the histological tumor boundary. The aim of this study was to evaluate the feasibility of combining prostate health index (PHI) and mpMRI to estimate the histological tumor diameter and determine the safety margin during treatment of prostate cancer. Methods We retrospectively enrolled 72 prostate cancer patients who underwent radical prostatectomy and had received PHI tests and mpMRI before surgery. We compared the discrepancy between histological and radiological tumor diameter stratified by Prostate Imaging-Reporting and Data System (PI-RADS) score, and then assessed the influence of PHI on the discrepancy between low PI-RADS (2 or 3) and high PI-RADS (4 or 5) groups. Results The mean radiological and histological tumor diameters were 1.60 cm and 2.13 cm, respectively. The median discrepancy between radiological and histological tumor diameter of PI-RADS 4 or 5 lesions was significantly greater than that of PI-RADS 2 or 3 lesions (0.50 cm, IQR (0.00–0.90) vs. 0.00 cm, IQR (−0.10–0.20), p = 0.02). In the low PI-RADS group, the upper limit of the discrepancy was 0.2 cm; so the safety margin could be set at 0.1 cm. In the high PI-RADS group, the upper limits of the discrepancy were 1.2, 1.6, and 2.2 cm in men with PHI 60; so the safety margin could be set at 0.6, 0.8, and 1.1 cm, respectively. Conclusions Radiological tumor diameter on mpMRI often underestimated the histological tumor diameter, especially for PI-RADS 4 or 5 lesions. Combining mpMRI and PHI may help to better estimate the histological tumor diameter. |
Databáze: | OpenAIRE |
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