IN VITRO STUDIES ON THE TUMOUR CYTOTOXICITY OF NORMAL, STIMULATED AND IMMUNOLOGICALLY ACTIVATED MOUSE MACROPHAGES
| Autor: | Hansen Jg, Severin Olesen Larsen, J. M. Rhodes, J. Bennedsen |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Cytotoxicity
Immunologic Lipopolysaccharides Male Lipopolysaccharide medicine.medical_treatment Immunology Biology Lymphocyte Activation Mice chemistry.chemical_compound Concanavalin A medicine Animals Cytotoxic T cell Neoplasm Phytohemagglutinins Cytotoxicity Lymphokines Mice Inbred C3H General Immunology and Microbiology Macrophages Lymphokine Neoplasms Experimental General Medicine Immunotherapy Macrophage Activation medicine.disease Molecular biology In vitro Mice Inbred C57BL chemistry Cell culture Female |
| Zdroj: | Acta Pathologica Microbiologica Scandinavica Series C: Immunology. :27-32 |
| ISSN: | 0108-0202 |
| DOI: | 10.1111/j.1699-0463.1982.tb01413.x |
| Popis: | Peripheral macrophages (MO) from mice injected with proteose-peptone (P), thioglycollate (T) medium or BCG and from mice undergoing a graft versus host (GVH) reaction were tested for their cytotoxicity towards three murine tumour cell lines. The ability of lipopolysaccharide (LPS) and lymphokines to increase cytotoxicity was also studied. TMO were only slightly cytotoxic and this cytotoxicity was not enhanced by LPS and lymphokines. PMO showed the same degree of cytotoxicity as TMO, but this could be enhanced by LPS and lymphokines. Resident macrophages (RMO) sometimes resembled TMO and sometimes PMO. BCGMO were highly cytotoxic and could not be further activated by LPS and lymphokines. GVHMO were moderately cytotoxic but could not be further activated by LPS and lymphokines in contrast to the MO from hybrid controls. |
| Databáze: | OpenAIRE |
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