Benefit of Multiple Sessions of Perilesional Repetitive Transcranial Magnetic Stimulation for an Effective Rehabilitation of Visuo-Spatial Function
| Autor: | R. Jarrett Rushmore, Antoni Valero-Cabré, Linda Afifi |
|---|---|
| Přispěvatelé: | Boston University School of Medicine, Universitat Oberta de Catalunya (UOC) |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_treatment
neurostimulació Parietal Lobe Neurociències neuroestimulación plasticitat cerebral media_common còrtex parietal posterior Rehabilitation General Neuroscience Parietal lobe no invasivo brain damage Transcranial Magnetic Stimulation corteza parietal posterior medicine.symptom Psychology psychological phenomena and processes neurostimulation modelo felino de negligencia visuoespacial medicine.medical_specialty posterior parietal cortex media_common.quotation_subject Neurociencias Brain damage dany cerebral feline model of visuospatial neglect behavioral disciplines and activities Article Neglect Perceptual Disorders Physical medicine and rehabilitation no invasiu daño cerebral noninvasive Orientation Neuroplasticity medicine Animals Neurostimulation Neurosciences Hemispatial neglect hemispatial neglect plasticidad cerebral Transcranial magnetic stimulation Disease Models Animal Space Perception model felí de negligència visoespacial Cats negligencia hemiespacial Neuroscience brain plasticity negligència hemisfèrica |
| Zdroj: | O2, repositorio institucional de la UOC Universitat Oberta de Catalunya (UOC) |
| Popis: | Noninvasive neurostimulation techniques have been used alone or in conjunction with rehabilitation therapy to treat the neurological sequelae of brain damage with rather variable therapeutic outcomes. One potential factor limiting a consistent success for such techniques may be the limited number of sessions carried out in patients, despite reports that their accrual may play a key role in alleviating neurological deficits long-term. In this study, we tested the effects of seventy consecutive sessions of perilesional high-frequency (10 Hz) repetitive transcranial magnetic stimulation (rTMS) in the treatment of chronic neglect deficits in a well-established feline model of visuospatial neglect. Under identical rTMS parameters and visuospatial testing regimes, half of the subjects improved in visuospatial orienting performance. The other half experienced either none or extremely moderate ameliorations in the neglected hemispace and displayed transient patterns of maladaptive visuospatial behavior. Detailed analyses suggest that lesion location and extent did not account for the behavioral differences observed between these two groups of animals. We conclude that multi-session perilesional rTMS regimes have the potential to induce functional ameliorations following focal chronic brain injury, and that behavioral performance prior to the onset of the rTMS treatment is the factor that best predicts positive outcomes for noninvasive neurostimulation treatments in visuospatial neglect. Non-invasive neurostimulation techniques have been used alone or in conjunction with rehabilitation therapy to treat the neurological sequelae of brain damage with rather variable therapeutic outcomes. One potential factor limiting a consistent success for such techniques may be the few sessions carried out in patients, despite reports that their accrual may play a key role in alleviating neurological deficits long-term. |
| Databáze: | OpenAIRE |
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