Magnetically triggered nanovehicles for controlled drug release as a colorectal cancer therapy

Autor: Jeng Kai Jiang, Wen-Yen Chiu, Ting-Yu Liu, Chi Hung Lin, Sung Chen Tsai, Chih Yung Yang, Chih-Yu Kuo, Li Ying Huang, Ruey Hwa Lu, Ming-Chien Yang, Tzu Yi Chan, Andri Hardiansyah
Rok vydání: 2016
Předmět:
Drug
Vinyl alcohol
Cell Survival
Surface Properties
Colorectal cancer
media_common.quotation_subject
Nanoparticle
Antineoplastic Agents
Nanotechnology
02 engineering and technology
010402 general chemistry
Ferric Compounds
01 natural sciences
Mice
chemistry.chemical_compound
Colloid and Surface Chemistry
Microscopy
Electron
Transmission
Cell Line
Tumor
Amphiphile
medicine
Animals
Doxorubicin
Physical and Theoretical Chemistry
media_common
chemistry.chemical_classification
Drug Carriers
Antibiotics
Antineoplastic
Chemistry
Surfaces and Interfaces
General Medicine
Polymer
021001 nanoscience & nanotechnology
medicine.disease
Tumor Burden
0104 chemical sciences
Drug Liberation
Magnetic Fields
Microscopy
Fluorescence
Delayed-Action Preparations
Nanoparticles
Surface modification
Colorectal Neoplasms
0210 nano-technology
human activities
Biotechnology
medicine.drug
Zdroj: Colloids and Surfaces B: Biointerfaces. 140:567-573
ISSN: 0927-7765
DOI: 10.1016/j.colsurfb.2015.11.008
Popis: Magnetic silica core/shell nanovehicles presenting atherosclerotic plaque-specific peptide-1 (AP-1) as a targeting ligand (MPVA-AP1 nanovehicles) have been prepared through a double-emulsion method and surface modification. Amphiphilic poly(vinyl alcohol) was introduced as a polymer binder to encapsulate various drug molecules (hydrophobic, hydrophilic, polymeric) and magnetic iron oxide (Fe3O4) nanoparticles. Under a high-frequency magnetic field, magnetic carriers (diameter: ca. 50 nm) incorporating the anti-cancer drug doxorubicin collapsed, releasing approximately 80% of the drug payload, due to the heat generated by the rapidly rotating Fe3O4 nanoparticles, thereby realizing rapid and accurate controlled drug release. Simultaneously, the magnetic Fe3O4 themselves could also kill the tumor cells through a hyperthermia effect (inductive heating). Unlike their ungrafted congeners (MPVA nanovehicles), the AP1-grafted nanovehicles bound efficiently to colorectal cancer cells (CT26-IL4Rα), thereby displaying tumor-cell selectivity. The combination of remote control, targeted dosing, drug-loading flexibility, and thermotherapy and chemotherapy suggests that magnetic nanovehicles such as MPVA-AP1 have great potential for application in cancer therapy.
Databáze: OpenAIRE
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