Crystal Structure of 5ʹ-Oxospiro-(fluorene-9,4ʹ-imidazolidine)-2ʹ-thione and Biological Activity of Its Derivatives
| Autor: | Neyko Stoyanov, H. Sbirkova-Dimitrova, Denica Blazheva, Yana Feodorova, Petja Marinova, Maria Kazakova, Marin Marinov, Victoria Sarafian, Aleksandar Slavchev |
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| Rok vydání: | 2021 |
| Předmět: |
antimicrobial activity
fluorenylspirohydantoins biology Chemistry Stereochemistry Biological activity General Chemistry Crystal structure Fluorene biology.organism_classification Antimicrobial Yeast chemistry.chemical_compound Imidazolidine X-ray 5ʹ-oxospiro-(fluorene-9 4ʹ-imidazolidine)-2ʹ-thione Candida albicans cytotoxic/antiproliferative effects Monoclinic crystal system |
| Zdroj: | Russian Journal of General Chemistry. 91:939-946 |
| ISSN: | 1608-3350 1070-3632 |
| DOI: | 10.1134/s1070363221050273 |
| Popis: | The presented study is devoted to the structural and biological properties of four derivatives of fluorenylspirohydantoin based on experimental data. The crystal structure of one of those, (9ʹ-fluorene)-spiro-5-(2-thiohydantoin), is described. The compound crystallizes in monoclinic crystal system and P21/c space group. We have pursued isolation of single crystals and biological activity tests of (9ʹ-fluorene)-spiro-5-hydantoin, (9ʹ-fluorene)-spiro-5-(2,4-dithiohydantoin), (9ʹ-fluorene)-spiro-5-(2-thiohydantoin), and (4ʹ,5ʹ-diaza-9ʹ-fluorene)-spiro-5-hydantoin. The compounds have been tested in both adherent and suspension tumor cell lines. The cell proliferation has been assessed by the WST-assay (Roche Applied Science). The antimicrobial activity against both Gram-positive, Gram-negative bacteria, and the yeast Candida albicans has been studied. |
| Databáze: | OpenAIRE |
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