Birdshot Retinochoroidopathy Associated with Hla-A29 Antigen and Immune Responsiveness to Retinal S-Antigen
| Autor: | A. Edward Maumenee, Robert B. Nussenblatt, Stephen J. Ryan, Kamal K. Mittal, W. Richard Green |
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| Rok vydání: | 1982 |
| Předmět: |
Adult
Male Birdshot retinochoroidopathy HLA-C Antigens Retina Immune system Antigen HLA Antigens medicine Humans Antigens Aged Arrestin HLA-A Antigens business.industry Histocompatibility Antigens Class II HLA-DR Antigens Middle Aged medicine.disease Birdshot chorioretinopathy Ophthalmology Retinal s antigen Chorioretinitis HLA-B Antigens Immunology Female business |
| Zdroj: | American Journal of Ophthalmology. 94:147-158 |
| ISSN: | 0002-9394 |
| DOI: | 10.1016/0002-9394(82)90069-1 |
| Popis: | Antigen HLA-A29 was present in 16 of 20 patients (80%) with birdshot retinochoroidopathy, but only in 31 of 418 controls (7.4%) (P less than .0001). The relative risk for this disease in persons possessing HLA-A29 antigen was 49.9, one of the highest reported. Of the 20 patients, 13 were also tested for evidence of an in vitro mitotic immune response to purified retinal S-antigen. Of these, 12 (92.3%) responded to the purified preparation, whereas one responded only to a crude retinal homogenate. The histopathologic and clinical findings in an eye from one of the responders to the S-antigen were similar to those in the disease induced in monkeys with the S-antigen. Our findings suggested that birdshot retinochoroidopathy has a genetic predisposition and that retinal autoimmunity, resulting from the S-antigen or other retinal antigens, plays a role in the manifestation of this disease. |
| Databáze: | OpenAIRE |
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