Cell-Penetrating Peptides: Design, Synthesis, and Applications
| Autor: | Elo Eriste, Dana Copolovici, Ülo Langel, Kent Langel |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Tumor targeting
Materials science Molecular Sequence Data Cell General Physics and Astronomy Peptide Cell-Penetrating Peptides Endocytosis Gene expression medicine Animals Humans Gene silencing General Materials Science Amino Acid Sequence chemistry.chemical_classification Drug Carriers General Engineering Combinatorial chemistry Cell biology Protein Transport medicine.anatomical_structure Design synthesis chemistry Drug Design Nucleic acid Nanoparticles |
| Zdroj: | ACS Nano. 8:1972-1994 |
| ISSN: | 1936-086X 1936-0851 |
| Popis: | The intrinsic property of cell-penetrating peptides (CPPs) to deliver therapeutic molecules (nucleic acids, drugs, imaging agents) to cells and tissues in a nontoxic manner has indicated that they may be potential components of future drugs and disease diagnostic agents. These versatile peptides are simple to synthesize, functionalize, and characterize yet are able to deliver covalently or noncovalently conjugated bioactive cargos (from small chemical drugs to large plasmid DNA) inside cells, primarily via endocytosis, in order to obtain high levels of gene expression, gene silencing, or tumor targeting. Typically, CPPs are often passive and nonselective yet must be functionalized or chemically modified to create effective delivery vectors that succeed in targeting specific cells or tissues. Furthermore, the design of clinically effective systemic delivery systems requires the same amount of attention to detail in both design of the delivered cargo and the cell-penetrating peptide used to deliver it. |
| Databáze: | OpenAIRE |
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