Complement factor I polymorphism is not associated with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy in a chinese population
| Autor: | Lvzhen Huang, Xiaoxin Li, Yaoyao Sun, Shanshan Li, Yong Cheng, Zhongtian Jin, Yujing Bai, Fei Yang |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Genotype Single-nucleotide polymorphism Complement factor I Logistic regression Polymerase Chain Reaction Polymorphism Single Nucleotide Polyps Asian People Internal medicine medicine Humans Allele Fluorescein Angiography Alleles Genetic association Aged Aged 80 and over Chinese population business.industry General Medicine Odds ratio Macular degeneration Middle Aged medicine.disease Sensory Systems Choroidal Neovascularization Surgery Ophthalmology Complement Factor I Case-Control Studies Spectrometry Mass Matrix-Assisted Laser Desorption-Ionization Wet Macular Degeneration Female business |
| Zdroj: | Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde. 232(1) |
| ISSN: | 1423-0267 |
| Popis: | Purpose: To identify the associations of the two complement factor I (CFI) polymorphisms rs10033900 and rs2285714 with risk of neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV) in a Chinese case-control study. Methods: A total of 900 subjects - 300 controls, 300 cases with nAMD and 300 cases with PCV - were included in the present study. Genomic DNA was extracted from venous blood leukocytes. The allelic variants of rs10033900 and rs2285714 were determined by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. The differences in allele distribution between the cases and controls were tested by a χ2 test with age and gender adjusted for by logistic regression analysis. We also performed a meta-analysis of the case-control studies of rs10033900 and rs2285714 based on the currently available evidence from the literature. The meta-analysis was conducted via an inverse-variance, fixed-effects model, as previously described. Results: No statistically significant association was observed between the two polymorphisms of CFI and AMD risk, including nAMD, PCV and combined AMD (p > 0.05 for all comparisons). By meta-analysis, we detected significant associations between both of the SNPs and late AMD, which is consistent with previous results (odds ratio, OR, rs10033900 = 0.814, p rs10033900 < 0.001; OR rs2285714 = 1.221, p rs2285714 < 0.001). For rs2285714, the results of the meta-analysis were less reliable due to its heterogeneity. Conclusions: In our case-control study, neither of the two SNPs most studied (rs10033900 or rs2285714) in the CFI gene was a risk factor for developing nAMD or PCV in a Chinese population. Additional large, comprehensive and well-designed association studies are needed to better understand the role of ethnicity and other gene interactions in the association between the CFI gene and AMD. |
| Databáze: | OpenAIRE |
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