Regenerative Potential of Perichondrium: A Tissue Engineering Perspective
| Autor: | D Gvaramia, J Kern, Nicole Rotter, Yvonne Jakob, Marcy Zenobi-Wong |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Adult
auricular reconstruction animal structures genetic structures Adolescent 0206 medical engineering Biomedical Engineering Bioengineering 02 engineering and technology Regenerative Medicine Biochemistry Biomaterials Tissue engineering perichondrium medicine Perichondrium Humans Child Tissue Engineering business.industry Cartilage Stem Cells Perspective (graphical) Cartilaginous part Anatomy 021001 nanoscience & nanotechnology musculoskeletal system 020601 biomedical engineering medicine.anatomical_structure cartilage tissue engineering chondrogenic progenitor cells embryonic structures 0210 nano-technology business Chondrogenesis |
| Zdroj: | Tissue Engineering Part B, Reviews, 28 (3) |
| Popis: | The clinical relevance of perichondrium was recognized more than a century ago. In children and adolescents, perichondrium is essential for the formation and growth of the cartilaginous part of craniofacial features and must be considered during reconstructive surgery in the head and neck area. Also in adults, perichondrium must be preserved during surgical intervention for adequate postoperative healing and cartilage maintenance. Furthermore, the regenerative function of perichondrium in the ribs enables the harvesting of the rib cartilage tissue for reconstruction of craniofacial features. With the advancement of tissue engineering, renewed attention has been focused on the perichondrium, because without this crucial tissue, the function of cartilage engineered for craniofacial reconstruction is incomplete and may not be suitable for long-term reconstructive goals. Furthermore, interest in the perichondrium was revived owing to its possible role as a microenvironment containing stem and progenitor cells. Here we will revisit seminal studies on the perichondrium and review the current literature to provide a holistic perspective on the importance of this tissue in the context of regenerative medicine. We will also highlight the functional significance of perichondrium for cartilage tissue engineering. Tissue Engineering Part B, Reviews, 28 (3) |
| Databáze: | OpenAIRE |
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