Clinical Cutaneous Features of Patients Infected With SARS-CoV-2 Hospitalized for Pneumonia: A Cross-sectional Study
| Autor: | Jean-François Emile, Stephanie Landowski, Elyanne Gault, Julia N'guyen Van Thanh, Pierre de Truchis, Isabelle Bourgault-Villada, Louis Jacob, Aurélie Le Gal, Jean-Louis Gaillard, Véronique Perronne, Aymeric Lanore, Nicolas Kiavue, Simon Bessis, Hélène Mascitti, Frédérique Bouchand, Aurélien Dinh, Faten El Sayed, Morgan Matt, Benjamin Davido, Valérie Sivadon-Tardy, Marie-Anne Rameix-Welti, Anne-Laure Roux, Elsa Salomon, Benjamin Bonsang, Christian Perronne, Soline Siméon, Clara Duran, Robert Carlier, Thibault Leblanc, Frédérique Moreau, Florence Assan |
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| Rok vydání: | 2020 |
| Předmět: |
Livedo
medicine.medical_specialty pandemics Major Articles Capillary leak 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Edema Biopsy medicine pneumonia 030212 general & internal medicine medicine.diagnostic_test business.industry COVID-19 medicine.disease Dermatology dermatology Editor's Choice Purpura Pneumonia AcademicSubjects/MED00290 Infectious Diseases Oncology Macular Rash exanthema medicine.symptom business Cytokine storm |
| Zdroj: | Open Forum Infectious Diseases |
| ISSN: | 2328-8957 |
| DOI: | 10.1093/ofid/ofaa394 |
| Popis: | Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a current pandemic worldwide. This virus can reach all organs and disturbs the immune system, leading to a cytokine storm in severe forms. We aimed to report cutaneous features among coronavirus disease 2019 (COVID-19) hospitalized patients. Methods We performed a cross-sectional study on 1 given day among all patients hospitalized in acute care for COVID-19 and included all patients with cutaneous features. Follow-up 48 hours later was obtained. Results Among 59 adult patients hospitalized on the day of the study in an infectious diseases ward for SARS-CoV-2 infection who were confirmed by molecular assay and/or radiological findings (computed tomography scan), 40 were included. Several cutaneous manifestations were found: macular exanthema (80%), face edema (32%), livedo (13%), urticarial rash (8%), purpura (5%), oral lichenoid lesions (33%), and conjunctivitis (18%). Cutaneous biopsy was performed in 17 patients. Histological findings showed mast cell hyperplasia (100%), superficial perivascular infiltrate of lymphocytes (94%), and superficial edema (47%) consistent with capillary leak. Conclusions Various dermatological signs can be encountered during COVID-19. A macular rash was the most frequent. All cutaneous features could be related to a vascular leak process. This cross-sectional study showed that cutaneous features are various among hospitalized patients with COVID-19. Macular rash was the most frequent and could be predictive of worsening. They seem related to an immune system disturbance, leading to a vascular leak process. |
| Databáze: | OpenAIRE |
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