A Concise Synthesis of Carolacton
| Autor: | William M. Wuest, Richard S. Brzozowski, Andrew J. Phillips, Michal S. Hallside |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Letter
Natural product Molecular Structure biology Stereochemistry Longest linear sequence Myxococcales Organic Chemistry Biofilm biology.organism_classification Biochemistry Combinatorial chemistry Streptococcus mutans 3. Good health chemistry.chemical_compound Carolacton chemistry Biofilms Macrolides Physical and Theoretical Chemistry |
| Zdroj: | Organic Letters |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/ol500004k |
| Popis: | A synthesis of carolacton, a myxobacterial natural product that has profound effects on Streptococcus mutans biofilms, is reported. The synthesis proceeds via a longest linear sequence of 14 steps from an Evans β-ketoimide and enabled preliminary evaluations of the effects of late-stage intermediates on S. mutans biofilms. These studies suggest that further investigations into carolacton's structure-function relationships are warranted. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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