Early mechanical selection of cell extrusion and extrusion signaling in cancer
| Autor: | Saranne J Mitchell, Jody Rosenblatt |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0303 health sciences
Programmed cell death Contraction (grammar) Cell Epithelial Cells Cell Biology Biology Actins Epithelium Article Cell biology 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Neoplasms Myosin medicine Humans Extrusion Process (anatomy) 030217 neurology & neurosurgery Ion channel Signal Transduction 030304 developmental biology |
| Zdroj: | Curr Opin Cell Biol |
| ISSN: | 0955-0674 |
| Popis: | Epithelial cells use the process of extrusion to promote cell death while preserving a tight barrier. To extrude, a cell and its neighbors contract actin and myosin circumferentially and basolaterally to seamlessly squeeze it out of the epithelium. Recent research highlights how early apical pulsatile contractions within the extruding cell might orchestrate contraction in three dimensions so that a cell extrudes out apically. Along with apical constrictions, studies of ion channels and mathematical modeling reveal how differential contraction between cells helps select specific cells to extrude. In addition, several studies have offered new insights into pathways that use extrusion to eliminate transformed cells or cause an aberrant form of extrusion that promotes cell invasion. |
| Databáze: | OpenAIRE |
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