Expression and significance of leukocyte membrane cofactor protein transcript in systemic lupus erythematosus
| Autor: | Bintili Biswas, Uma Kumar, Nibhriti Das |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Disease Severity of Illness Index Membrane Cofactor Protein Young Adult Rheumatology Severity of illness Active disease Leukocytes Humans Lupus Erythematosus Systemic Medicine Genetic Predisposition to Disease Young adult skin and connective tissue diseases Regulation of gene expression CD46 business.industry Case-control study Immune complex Gene Expression Regulation Case-Control Studies Immunology Female business Follow-Up Studies |
| Zdroj: | Lupus. 21:517-525 |
| ISSN: | 1477-0962 0961-2033 |
| DOI: | 10.1177/0961203311434104 |
| Popis: | Membrane cofactor protein (MCP) is a complement regulatory protein ubiquitously expressed on most nucleated cells. Since MCP protects autologous cells from complement-mediated injury, it is suggested to have a protective role against the self-tissue damage in inflammatory conditions such as systemic lupus erythematosus (SLE). However, the relevance of MCP in human SLE is not well explored. To assess the significance of MCP in SLE, we studied expression of leukocyte MCP transcript in 60 healthy individuals (controls) and 60 patients with SLE and correlated that with the levels of circulating immune complex (CIC), C3, C3d and SLEDAI scores. The levels of leukocyte MCP transcript were significantly higher ( p |
| Databáze: | OpenAIRE |
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