N-(2-Chloropyrimidin-4-yl)-N,2-dimethyl-2H-indazol-6-amine

Autor:	Haofei Qi, Bing-Ni Liu, Deng-Ke Liu, Mo Liu
Jazyk:	angličtina
Rok vydání:	2010
Předmět:	Indazole Hydrogen bond General Chemistry Dihedral angle Condensed Matter Physics Ring (chemistry) Bioinformatics Medicinal chemistry Organic Papers Crystal lcsh:Chemistry chemistry.chemical_compound chemistry lcsh:QD1-999 General Materials Science Amine gas treating Derivative (chemistry)
Zdroj:	Acta Crystallographica Section E, Vol 66, Iss 11, Pp o2955-o2955 (2010) Acta Crystallographica Section E: Structure Reports
ISSN:	1600-5368
Popis:	In the title compound, C13H12ClN5, which is a derivative of the antitumor agent pazopanib {systematic name: 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzolsulfonamide}, the indazole and pyrimidine fragments form a dihedral angle of 62.63 (5)°. In the crystal, pairs of molecules related by twofold rotational symmetry are linked into dimers through π–π interactions between the indazole ring systems [centroid–centroid distance = 3.720 (2) Å]. Weak intermolecular C—H...N hydrogen bonds further assemble these dimers into columns propagated in [001].
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c679120c1de933fb41d27ce616243257 http://scripts.iucr.org/cgi-bin/paper?S1600536810042753 Zobrazit plný text záznamu