Synergistic anti-inflammatory activities of a new flavone and other flavonoids from Tephrosia hildebrandtii vatke

Autor:	Sebastian Zühlke, Kibrom Gebreheiwot Bedane, Michael Spiteller, Albert Ndakala, Yolande Ikala Openda, Richard Oriko Owor, George Ong’amo, Solomon Derese
Rok vydání:	2020
Předmět:	chemistry.chemical_classification biology Traditional medicine medicine.drug_class Tephrosia Organic Chemistry Flavonoid Plant Science Fabaceae biology.organism_classification Biochemistry Anti-inflammatory Analytical Chemistry chemistry medicine
Zdroj:	Natural Product Research. 35:4486-4493
ISSN:	1478-6427 1478-6419
Popis:	A new flavone, named hildeflavone (1) along with 7 other known flavonoids were isolated from the aerial parts of Tephrosia hildebrandtii Vatke. Their characterisation was based on NMR and MS data analysis. The anti-inflammatory properties of the crude extract, isolated compounds and combination of the compounds were investigated in lipopolysaccharide (LPS)-stimulated peripheral blood mononuclear cells (PBMCs). Treatment of the LPS-stimulated PBMCs with the isolated flavonoids at a concentration of 100 µM significantly reduced the production of interleukins (IL-1β, IL-2 and IL-6), interferon-gamma (IFN-γ), granulocyte macrophage-colony stimulating factor (GM-CSF) and tumour necrosis factor-alpha (TNF-α). It was also found that the combination of a flavone and flavanones exhibited remarkable synergistic anti-inflammatory effects on the production of the cytokines.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c675667234e10d4338f997872e923de6 https://doi.org/10.1080/14786419.2020.1736065 Zobrazit plný text záznamu