Immunity in young adult survivors of childhood leukemia is similar to the elderly rather than age-matched controls: Role of cytomegalovirus
| Autor: | Sharon R Lewin, Hany Ariffin, Shahrul Bahyah Kamaruzzaman, Su Han Lum, Noor Kamila Abdullah, Reena Rajasuriar, Sayyidatul Syahirah Abdul Ghafar, Ling Ling Chua, Yin Ling Woo, Adeeba Kamarulzaman, Mohamad Shafiq Azanan |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine Adolescent Childhood leukemia Immunology Cytomegalovirus Antibodies Viral Lymphocyte Activation Systemic inflammation Immunocompromised Host Young Adult 03 medical and health sciences 0302 clinical medicine Immune system Risk Factors T-Lymphocyte Subsets Odds Ratio medicine Humans Immunology and Allergy Survivors Young adult Aged Inflammation Leukemia biology business.industry C-reactive protein Age Factors Immunity Middle Aged medicine.disease Pediatric cancer humanities 030104 developmental biology Case-Control Studies Immunoglobulin G 030220 oncology & carcinogenesis Cytomegalovirus Infections biology.protein Female medicine.symptom Cell activation business Biomarkers |
| Zdroj: | European Journal of Immunology. 46:1715-1726 |
| ISSN: | 0014-2980 |
| DOI: | 10.1002/eji.201646356 |
| Popis: | Many treatment complications that occur late in childhood cancer survivors resemble age-related comorbidities observed in the elderly. An immune phenotype characterized by increased immune activation, systemic inflammation, and accumulation of late-differentiated memory CD57(+) CD28(-) T cells has been associated with comorbidities in the elderly. Here, we explored if this phenotype was present in young adult leukemia survivors following an average of 19 years from chemotherapy and/or radiotherapy completion, and compared this with that in age-matched controls. We found that markers of systemic inflammation-IL-6 and human C-reactive protein and immune activation-CD38 and HLA-DR on T cells, soluble CD (sCD)163 from monocytes and macrophages-were increased in survivors compared to controls. T-cell responses specific to cytomegalovirus (CMV) were also increased in survivors compared to controls while CMV IgG levels in survivors were comparable to levels measured in the elderly (>50years) and correlated with IL-6, human C-reactive protein, sCD163, and CD57(+) CD28(-) memory T cells. Immune activation and inflammation markers correlated poorly with prior chemotherapy and radiotherapy exposure. These data suggest that CMV infection/reactivation is strongly correlated with the immunological phenotype seen in young childhood leukemia survivors and these changes may be associated with the early onset of age-related comorbidities in this group. |
| Databáze: | OpenAIRE |
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