Engineering Tolerance into Transplanted β Cell Lines
| Autor: | Sandra Cottet, Bernard Thorens, Philippe Dupraz |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Tumor Necrosis Factor-alpha
General Neuroscience medicine.medical_treatment Islets of Langerhans Transplantation Engineering tolerance Biology General Biochemistry Genetics and Molecular Biology Cell Line Genes bcl-2 Cell biology Interferon-gamma Cytokine History and Philosophy of Science Intracellular signaling pathways Cell culture Immune Tolerance medicine Animals Genetic Engineering Gene Cell Division Function (biology) Interleukin-1 Signal Transduction |
| Zdroj: | Annals of the New York Academy of Sciences. 944:267-270 |
| ISSN: | 1749-6632 0077-8923 |
| DOI: | 10.1111/j.1749-6632.2001.tb03838.x |
| Popis: | In this paper we explore the possibility of improving, by genetic engineering, the resistance of insulin-secreting cells to the metabolic and inflammatory stresses that are anticipated to limit their function and survival when encapsulated and transplanted in a type 1 diabetic environment. We show that transfer of the Bcl-2 antiapoptotic gene, and of genes specifically interfering with cytokine intracellular signaling pathways, greatly improves resistance of the cells to metabolic limitations and inflammatory stresses. |
| Databáze: | OpenAIRE |
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