Interleukin-1 System in CNS Stress: Seizures, Fever, and Neurotrauma

Autor:	Marianne Schultzberg, Erik Danielsson, Tamas Bartfai, Manuel Sanchez-Alavez, Bruno Conti, Siv Andell-Jonsson, Annamaria Vezzani
Rok vydání:	2007
Předmět:	Central Nervous System Agonist Fever medicine.drug_class Traumatic brain injury medicine.medical_treatment Interleukin-1beta Mice Transgenic Inflammation Pharmacology Biology Infections General Biochemistry Genetics and Molecular Biology Proinflammatory cytokine Mice History and Philosophy of Science Seizures Febrile seizure medicine Animals Humans Neurons Neurotransmitter Agents General Neuroscience medicine.disease Receptor antagonist Disease Models Animal Interleukin 1 Receptor Antagonist Protein Anticonvulsant Interleukin 1 receptor antagonist Brain Injuries Immunology medicine.symptom
Zdroj:	Annals of the New York Academy of Sciences. 1113:173-177
ISSN:	0077-8923
DOI:	10.1196/annals.1391.022
Popis:	Proteins of the interleukin-1 (IL-1) system include the secreted agonist IL-1beta, and the receptor antagonist IL-1ra, both competing for binding to the IL-1 receptor (IL-1R). IL-1beta and IL-1ra are highly inducible under different forms of stress, such as excitatory neurotransmitter excess occurring during seizures, in infection and inflammation, and during neurotrauma. In each of these conditions induction of IL-1beta precedes that of IL-1ra, resulting in up to 10-20-fold elevation of IL-1beta concentrations. Consequently, IL-1beta induces the elevation of other proinflammatory molecules, including IL-6, IL-1R1, COX2, and iNOS, as well as of IL-1ra. Elevation of IL-1ra is of key importance for quenching the inflammatory response at the IL-1R1 as part of an autoregulatory loop. In seizures, IL-1ra is a strong anticonvulsant and in IL-1beta-dependent fever, a powerful antipyretic. In traumatic brain injury (TBI), the ability of patients to mount an IL-1ra response, as measured in the CSF, strongly correlated with the neurological outcome. Selective induction or pharmacological application of IL-1ra may be sparing neurons in seizures and neurotrauma.
Databáze:	OpenAIRE
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