Characterizations and Antibacterial Efficacy of Chitosan Oligomers Synthesized by Microwave-Assisted Hydrogen Peroxide Oxidative Depolymerization Method for Infectious Wound Applications
| Autor: | Hoai Thi-Thu Nguyen, Lam Dai Tran, Cheng-Chung Chang, Vinh Khanh Doan, Phuong Thu Ha, Thi-Hiep Nguyen, Khanh Loan Ly, Minh Hieu Ho, Toi Van Vo, Nhi Thao-Ngoc Dang, Quyen Ngoc Tran, Nam Minh-Phuong Tran, Trinh Phuong-Thi Ho |
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| Rok vydání: | 2021 |
| Předmět: |
Technology
poly(ɛ-caprolactone) (PCL) Oxidative phosphorylation wound dressing Article Chitosan chemistry.chemical_compound Minimum inhibitory concentration General Materials Science Hydrogen peroxide microwave irradiation electrospinning Microscopy QC120-168.85 Minimum bactericidal concentration Depolymerization QH201-278.5 chitosan oligomers (OCS) Engineering (General). Civil engineering (General) tablet-compressing Antimicrobial TK1-9971 Descriptive and experimental mechanics chemistry Microwave irradiation Electrical engineering. Electronics. Nuclear engineering TA1-2040 multi-spraying coating Nuclear chemistry |
| Zdroj: | Materials Volume 14 Issue 16 Materials, Vol 14, Iss 4475, p 4475 (2021) |
| ISSN: | 1996-1944 |
| DOI: | 10.3390/ma14164475 |
| Popis: | The use of naturally occurring materials with antibacterial properties has gained a great interest in infected wound management. Despite being an abundant resource in Vietnam, chitosan and its derivatives have not yet been intensively explored for their potential in such application. Here, we utilized a local chitosan source to synthesize chitosan oligomers (OCS) using hydrogen peroxide (H2O2) oxidation under the microwave irradiation method. The effects of H2O2 concentration on the physicochemical properties of OCS were investigated through molecular weight, degree of deacetylation, and heavy metal contamination for optimization of OCS formulation. Then, the antibacterial inhibition was examined the minimum inhibitory concentration and minimum bactericidal concentration (MIC and MBC) of OCS-based materials were determined against common skin-inhabitant pathogens. The results show that the local Vietnamese chitosan and its derivative OCS possessed high-yield purification while the molecular weight of OCS was inversely proportional and proportional to the concentration of H2O2, respectively. Further, the MIC and MBC of OCS ranged from 3.75 to less than 15 mg/mL and 7.5–15 mg/mL, respectively. Thus, OCS-based materials induce excellent antimicrobial properties and can be attractive for wound dressings and require further investigation. |
| Databáze: | OpenAIRE |
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