Nerve-regenerating effect of 15-deoxyspergualin: Peripheral nerve allotransplants in the rat
| Autor: | Shinya Kawai, Tatsuaki Akino, Keiichi Muramatsu, Hisashi Yamamoto, Kazuteru Doi, Mitsunori Shigetomi |
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| Rok vydání: | 1996 |
| Předmět: |
medicine.medical_specialty
chemical and pharmacologic phenomena Guanidines Transplantation Autologous Immune system Peripheral nerve medicine Animals Transplantation Homologous Orthopedics and Sports Medicine Peripheral Nerves business.industry Regeneration (biology) Rats Inbred Strains Sciatic Nerve Nerve Regeneration Rats Surgery Saphenous nerve surgical procedures operative Rats Inbred Lew Cyclosporine Sciatic nerve business Immunosuppressive Agents |
| Zdroj: | Acta Orthopaedica Scandinavica. 67:399-402 |
| ISSN: | 0001-6470 |
| DOI: | 10.3109/17453679609002339 |
| Popis: | We studied the effect of two immunosuppressive agents, 15-deoxyspergualin and cyclosporine A, on various nerve allografts in inbred rats whose major histocompatibility complex was mismatched. As allografts, we used the sciatic nerve (20 mm) and the saphenous nerve (20 mm). We found that 1) fresh peripheral nerve allografts with a short course of 15-deoxyspergualin and cyclosporine A therapy induced more regenerated axons than autografts did, 2) a short course of 15-deoxyspergualin therapy provided better nerve regeneration than cyclosporine A therapy in all forms of nerve allografts and large caliber nerve allografts induced more regenerated axons. |
| Databáze: | OpenAIRE |
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