Antisolvent crystallization of a cardiotonic drug in ionic liquids: Effect of mixing on the crystal properties
| Autor: | Espitalier Fabienne, Letourneau Jean-Jacques, Ré Maria Inês, Resende de Azevedo Jacqueline |
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| Přispěvatelé: | Centre de recherche d'Albi en génie des procédés des solides divisés, de l'énergie et de l'environnement (RAPSODEE), Centre National de la Recherche Scientifique (CNRS)-IMT École nationale supérieure des Mines d'Albi-Carmaux (IMT Mines Albi), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT) |
| Rok vydání: | 2017 |
| Předmět: |
Materials science
Dissolution enhancement Mixing (process engineering) 02 engineering and technology Poorly water-soluble drug law.invention Inorganic Chemistry chemistry.chemical_compound [CHIM.GENI]Chemical Sciences/Chemical engineering 020401 chemical engineering law Phase (matter) Materials Chemistry Organic chemistry [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering 0204 chemical engineering Crystallization Solubility Antisolvent crystallization Poorly water-soluble chug Dissolution 021001 nanoscience & nanotechnology Condensed Matter Physics Ionic liquids Solvent [SDV.SP.PG]Life Sciences [q-bio]/Pharmaceutical sciences/Galenic pharmacology Chemical engineering chemistry Ionic liquid Particle size 0210 nano-technology |
| Zdroj: | Journal of Crystal Growth Journal of Crystal Growth, Elsevier, 2017, Industrial Crystallization and Precipitation in France (CRISTAL-8), May 2016, Rouen (France), 472 (SI), pp.29-34. ⟨10.1016/j.jcrysgro.2016.12.057⟩ |
| ISSN: | 0022-0248 |
| Popis: | International audience; LASSBio-294 (3,4-methylenedioxybenzoyl-2-thienylhydrazon) is a poorly soluble drug which has been proposed to have major advantages over other cardiotonic drugs. Poorly water soluble drugs present limited bioavailability due to their low solubility and dissolution rate. An antisolvent crystallization processing can improve the dissolution rate by decreasing the crystals particle size. However, LASSBio-294 is also poorly soluble in organic solvents and this operation is limited. In order to open new perspectives to improve dissolution rate, this work has investigated LASSBio-294 in terms of its antisolvent crystallization in 1-ethyl-3-methylimidazolium methyl phosphonate [emim][CH3O(H)PO2] as solvent and water as antisolvent. Two modes of mixing are tested in stirred vessel with different pre-mixers (Roughton or T-mixers) in order to investigate the mixing effect on the crystal properties (crystalline structure, particle size distribution, residual solvent and in vitro dissolution rate). Smaller drug particles with unchanged crystalline structure were obtained. Despite the decrease of the elementary particles size, the recrystallized particles did not achieve a better dissolution profile. However, this study was able to highlight a certain number of findings such as the impact of the hydrodynamic conditions on the crystals formation and the presence of a gel phase limiting the dissolution rate. |
| Databáze: | OpenAIRE |
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