Enteric Dysganglionosis Resembling Intestinal Neuronal Dysplasia in a Foal With Bacterial Colitis
| Autor: | Erin M. Quist, Andy Ambrus, D. K. Giri, R. W. Storts, G. R. Bratton, Jenifer R. Gold, Brian F. Porter |
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| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Pathology Plexus Muscularis mucosae Intestinal neuronal dysplasia General Veterinary biology Colitis medicine.disease Gastroenterology Small intestine Diagnosis Differential Fatal Outcome medicine.anatomical_structure Animals Newborn Foal Dysplasia Internal medicine biology.animal medicine Animals Horse Diseases Enteric nervous system Horses |
| Zdroj: | Veterinary Pathology. 47:654-657 |
| ISSN: | 1544-2217 0300-9858 |
| Popis: | A 5-day-old quarter horse colt with a history of hypothermia, agonal breathing, and diarrhea was euthanized. At necropsy, numerous slightly raised, discrete, closely approximated submucosal nodules were observed in the colon and small intestine. Histologically, these nodules were composed of expanded submucosal mesenchyme that contained numerous neurons either individually or in ganglia. Thirty-two percent of these ganglia included 8 or more neurons, in contrast to 6% in an age-matched foal. Some nodules had necrosuppurative inflammation with vasculitis, thrombosis, and bacterial colonization. A few heterotopic neurons were randomly distributed in the mucosa and the muscularis mucosa. Histologic changes were most consistent with intestinal neuronal dysplasia, a disease of the submucosal plexus described in humans. |
| Databáze: | OpenAIRE |
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