Markov model into the cost-utility over five years of etanercept and infliximab compared with usual care in patients with active ankylosing spondylitis
| Autor: | J. Sieper, A Boendermaker, Annelies Boonen, D. van der Heijde, J Brandt, Robert Landewé, Sj van der Linden, J L Severens, Jürgen Braun |
|---|---|
| Přispěvatelé: | Other departments |
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male musculoskeletal diseases medicine.medical_specialty Time Factors Immunology Drug Costs Receptors Tumor Necrosis Factor General Biochemistry Genetics and Molecular Biology Etanercept Cohort Studies Rheumatology Internal medicine medicine Humans Immunology and Allergy Spondylitis Ankylosing Practice Patterns Physicians' skin and connective tissue diseases BASDAI Randomized Controlled Trials as Topic Ankylosing spondylitis business.industry Antibodies Monoclonal Middle Aged Patient Acceptance of Health Care medicine.disease Infliximab Markov Chains Quality-adjusted life year Extended Report stomatognathic diseases Models Economic Treatment Outcome Antirheumatic Agents Immunoglobulin G Rheumatoid arthritis Acute Disease Physical therapy Female Quality-Adjusted Life Years business medicine.drug Cohort study |
| Zdroj: | Annals of the rheumatic diseases, 65(2), 201-208. BMJ Publishing Group |
| ISSN: | 0003-4967 |
| DOI: | 10.1136/ard.2004.032565 |
| Popis: | To estimate the incremental cost-utility of etanercept and infliximab compared with usual care in active ankylosing spondylitis. A Markov model over five years with cycle times of three months was computed. Patients included all had active disease, defined as Bath ankylosing spondylitis disease activity index (BASDAI) >or=4 and could reach low disease activity, defined as BASDAI or=4, leading to cessation of treatment, or toxicity, leading to cessation of treatment if major. Probabilities for efficacy, relapse, and toxicity were derived from two European randomised controlled trials. Utilities and costs assigned to the BASDAI disease states were derived from a two year observational Dutch cohort. In sensitivity analyses probabilities of effectiveness, toxicity, costs, and utilities were varied. Over five years the total quality adjusted life years varied from 2.57 to 2.89 for usual care, compared with 3.13 to 3.42 and 3.07 to 3.35 for etanercept or infliximab. Cumulative costs were between 49,555 to 69,982 for usual care compared with 59,574 to 91,183 or 28,3330 to 106,775 for etanercept and infliximab. This resulted in incremental cost-utility ratios varying between 42,914 and 123,761 per QALY for etanercept compared with usual care and 67,207 to 237,010 for infliximab. The model was sensitive to drug prices. Etanercept and infliximab have large clinical effects in ankylosing spondylitis. The present model suggests the high drug costs restricts efficient use in all patients who have a BASDAI >4. The validity of the model is limited by insufficient insight in the natural course of the disease and long term effectiveness and toxicity of TNFalpha inhibitors |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|