A Facile, Catalytic, and Environmentally Benign Method for Selective Deprotection of tert-Butyldimethylsilyl Ether Mediated by Phosphomolybdic Acid Supported on Silica Gel
| Autor: | Sundarababu Baskaran, G. D. Kishore Kumar |
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| Rok vydání: | 2005 |
| Předmět: |
synthesis
phosphomolybdic acid Alkyne Ether Isopropylidene acetal Catalysis chemistry.chemical_compound Mild conditions Silicon compounds Organic chemistry drug selectivity Reaction kinetics environmental monitoring chemistry.chemical_classification silicon dioxide analytic method tert butyl dimethylsilyl ether catalysis Chemoselective deprotection Alkene Silica gel silica gel Organic Chemistry Acetal General Medicine unclassified drug reaction analysis chemistry Alkynes chemical analysis Solvents Phosphomolybdic acid Azide aqueous solution oxidation reduction reaction molybdic acid |
| Zdroj: | ChemInform. 36 |
| ISSN: | 1522-2667 0931-7597 |
| DOI: | 10.1002/chin.200543074 |
| Popis: | An environmentally benign PMA supported on SiO2 is found to be an efficient catalyst for the chemoselective deprotection of TBDMS ethers under very mild conditions. Various labile functional groups such as isopropylidene acetal, OTBDPS, OTHP, Oallyl, OBn, alkene, alkyne, OAc, OBz, N-Boc, N-Cbz, N-Fmoc, mesylate, and azide are found to be stable under the reaction conditions. This "truly catalytic" heterogeneous reaction does not require aqueous workup, and the supported catalyst and the solvent can be readily recovered and recycled. ? 2005 American Chemical Society. |
| Databáze: | OpenAIRE |
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