Effects of Chronic and Acute Ozone Exposure on Lipid Peroxidation and Antioxidant Capacity in Healthy Young Adults
| Autor: | Mehrdad Arjomandi, Connie Chen, Nina Holland, John R. Balmes, Ira B. Tager |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Isoprostane Ozone oxidative injury Health Toxicology and Mutagenesis Physiology antioxidant capacity isoprostane 010501 environmental sciences Isoprostanes 01 natural sciences Antioxidants Lipid peroxidation Oxidative damage Cohort Studies 03 medical and health sciences chemistry.chemical_compound Humans Ozone exposure Young adult Students plasma 030304 developmental biology 0105 earth and related environmental sciences Pollutant 0303 health sciences Sex Characteristics Research lifetime exposure Public Health Environmental and Occupational Health lipid peroxidation Environmental Exposure 3. Good health Antioxidant capacity ozone chemistry 13. Climate action Health Immunology FRAP Female Biomarkers |
| Zdroj: | Environmental Health Perspectives |
| ISSN: | 1552-9924 0091-6765 |
| Popis: | Background There is growing evidence for the role of oxidative damage in chronic diseases. Although ozone (O3) is an oxidant pollutant to which many people are exposed, few studies have examined whether O3 induces oxidative stress in humans. Objectives This study was designed to assess the effect of short-and long-term O3 exposures on biomarkers of oxidative stress in healthy individuals. Methods Biomarkers of lipid peroxidation, 8-isoprostane (8-iso-PGF), and antioxidant capacity ferric reducing ability of plasma (FRAP) were analyzed in two groups of healthy college students with broad ranges of ambient O3 exposure during their lifetimes and previous summer recess either in Los Angeles (LA, n = 59) or the San Francisco Bay Area (SF, n = 61). Results Estimated 2-week, 1-month, and lifetime O3 exposures were significantly correlated with elevated 8-iso-PGF. Elevated summertime exposures resulted in the LA group having higher levels of 8-iso-PGF than the SF group (p = 0.02). Within each location, males and females had similar 8-iso-PGF. No regional difference in FRAP was observed, with significantly higher FRAP in males in both groups (SF: p = 0.002; LA: p = 0.004). An exposure chamber substudy (n = 15) also showed a significant increase in 8-iso-PGF as well as an inhibition of FRAP immediately after a 4-hr exposure to 200 ppb O3, with near normalization by 18 hr in both biomarkers. Conclusions Long-term exposure to O3 is associated with elevated 8-iso-PGF, which suggests that 8-iso-PGF is a good biomarker of oxidative damage related to air pollution. |
| Databáze: | OpenAIRE |
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