Low molecular weight heparin given the evening before surgery compared with conventional low-dose heparin in prevention of thrombosis
| Autor: | Thomas Mätzsch, J Frisell, Bo Risberg, S. Törngren, H Ljungner, U S Burmark, H. Onarheim, F-G. Ljungstrom, David Bergqvist, Per Örtenwall, O. Guilbaud, A. Horn, Hallböök T, A Lindhagen |
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| Rok vydání: | 1988 |
| Předmět: |
Adult
Male medicine.medical_specialty Evening medicine.drug_class Deep vein Premedication Low molecular weight heparin Hemorrhage Random Allocation Postoperative Complications Double-Blind Method Abdomen medicine Humans Prospective Studies Prospective cohort study Intraoperative Complications Aged Aged 80 and over Clinical Trials as Topic business.industry Heparin Anticoagulant Thrombosis Heparin Low-Molecular-Weight Middle Aged medicine.disease Surgery medicine.anatomical_structure Anesthesia Female business Low dose heparin medicine.drug |
| Zdroj: | The British journal of surgery. 75(9) |
| ISSN: | 0007-1323 |
| Popis: | A prospective randomized double-blind trial was performed comparing conventional low-dose heparin with a low molecular weight heparin fragment for thromboprophylaxis in elective general abdominal surgical patients. The first dose of the heparin fragment was given the evening before surgery, and further doses were given thereafter every evening. There were 1002 analysable patients, 826 having received correct prophylaxis. Of these 1002 patients, 64 per cent were operated on for malignant disease. A total of 20 patients died, 10 in each group. The 5·0 per cent, P = 0·02). The frequency of bleeding was 6·7 per cent among patients with correct prophylaxis with the heparin fragment (9·2–5·0 per cent, P = 0·02). The frequency of bleeding was 6·7 per cent among the heparin fragment patients and 2·7 per cent among the patients given conventional heparin (P = 0·01), but all bleeds were of minor degree and there was no difference in the reoperation rate for bleeding, or in the transfusion requirements. Local pain at the injection site was reported significantly less often among patients given the heparin fragment. |
| Databáze: | OpenAIRE |
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