Strategies to expand the therapeutic potential of superoxide dismutase by exploiting delivery approaches
| Autor: | Franco Dosio, Arianna Carolina Rosa, Niccolò Cavi, Giorgia Meineri, Daniele Corsi, Daniela Gastaldi, Natascia Bruni |
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| Rok vydání: | 2021 |
| Předmět: |
Antioxidant
Drug Compounding medicine.medical_treatment Administration Oral Biological Availability 02 engineering and technology Pharmacology medicine.disease_cause Biochemistry Superoxide dismutase 03 medical and health sciences Structural Biology medicine Nanotechnology Molecular Biology Micelles 030304 developmental biology 0303 health sciences Preventive strategy biology Superoxide Dismutase business.industry General Medicine 021001 nanoscience & nanotechnology Oxidative Stress Formulation Drug delivery Liposomes biology.protein Nanoparticles 0210 nano-technology business Oxidative stress |
| Zdroj: | International Journal of Biological Macromolecules. 168:846-865 |
| ISSN: | 0141-8130 |
| Popis: | The overproduction of free radicals can cause oxidative-stress damage to a range of biomolecules, and thus potentially contribute to several pathologies, from neurodegenerative disorders to cardiovascular diseases and metabolic disorders. Endogenous antioxidant enzymes, such as superoxide dismutase (SOD), play an important role in diminishing oxidative stress. SOD supplementation could therefore be an effective preventive strategy to reduce the risk of free-radical overproduction. However, the efficacy of SOD administration is hampered by its rapid clearance. Several different approaches to improve the bioavailability of SOD have been explored in recent decades. This review intends to describe the rationale that underlie the various approaches and chemical strategies that have led to the most recent advances in SOD delivery. This critical description includes SOD conjugates, SOD loaded into particulate carriers (micelles, liposomes, nanoparticles, microparticles) and the most promising and suitable formulations for oral delivery, with a particular emphasis on reports of preclinical/clinical results. Likely future directions are also considered and reported. |
| Databáze: | OpenAIRE |
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