Auditory Midbrain Implant
| Autor: | Gerrit Paasche, Hubert H. Lim, Thomas Lenarz, Alexandru C. Stan, Günter Reuter, Minoo Lenarz, Nadine Marquardt, Uta Reich, Marc N. Klingberg |
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| Rok vydání: | 2007 |
| Předmět: |
Inferior colliculus
Pathology medicine.medical_specialty Deep brain stimulation Deep Brain Stimulation medicine.medical_treatment Prosthesis Implantation Stimulation Deafness Mesencephalon Glial Fibrillary Acidic Protein medicine Neuropil Animals Neurons Behavior Animal business.industry Auditory Threshold Anatomy Inferior Colliculi Sensory Systems Electrodes Implanted Disease Models Animal Brain implant Cochlear Implants medicine.anatomical_structure Otorhinolaryngology Cats Neurology (clinical) Implant Neuron Otologic Surgical Procedures business Neuroglia |
| Zdroj: | Otology & Neurotology. 28:1045-1052 |
| ISSN: | 1531-7129 |
| Popis: | Hypothesis Chronic implantation and electric stimulation with a human prototype auditory midbrain implant (AMI) array within the inferior colliculus achieves minimal neuronal damage and does not cause any severe complications. Background An AMI array has been developed for patients with neural deafness and, based on animal studies, has shown to possess potential as an auditory prosthesis in humans. To investigate the safety of the AMI for clinical use, we characterized the histomorphologic effects of chronic implantation and stimulation within its target structure, the inferior colliculus. Methods Eight cats were chronically implanted for 3 months, and histologic sections were analyzed to assess long-term tissue effects. Four of the 8 cats were additionally stimulated for 60 days (4 h/d) starting 4 weeks after implantation to assess if clinically relevant stimuli further affected the tissue response. Results In general, both neurons and neuropil surrounding the implant track were apparently unaffected, whereas a fibrillary sheath (approximately 50 microm thick) developed around the array. There was a significant decrease in neuron density 50 to 100 microm away from the track with a significantly elevated number of glial cells out to approximately 250 to 350 microm. Chronic stimulation seemed to improve the tissue response and neuronal survival around the implant, although further studies are needed to confirm this finding. Conclusion The histomorphologic effects and extent of neuronal damage observed for our AMI array are similar to those of other neural implants currently and safely used in humans. The minimal tissue damage surrounding the implanted array is encouraging with regard to the safety of the array for human use. |
| Databáze: | OpenAIRE |
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