Inflammatory and procoagulant cytokine levels during pregnancy as predictors of adverse obstetrical complications
| Autor: | Debra Hoppensteadt, M. R. Lassen, Josephine Cunanan, Jawed Fareed, Anita Sylvest Andersen, Shannon Dibble |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
medicine.medical_specialty medicine.medical_treatment Inflammation Young Adult Pregnancy medicine Humans Obstetrical complications Plasma samples business.industry Obstetrics Interleukin-6 Hematology General Medicine Middle Aged medicine.disease Pregnancy Complications Increased risk Cytokine Cytokine Network Hemostasis Cytokines Female medicine.symptom business |
| Zdroj: | Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. 20(2) |
| ISSN: | 1938-2723 |
| Popis: | Introduction: Disturbances in cytokine networks are believed to be associated with increased risk of adverse pregnancy complications. Methods: Plasma samples collected from pregnant women with preterm deliveries, high-risk pregnancy complications including postpartum hemorrhage, hypertensive disorders, and multiple gestations, and normal pregnancies were analyzed at different periods throughout gestation and postpartum. Interleukin (IL) 1β , IL-6, IL-8, IL-10, tumor necrosis factor α, and antiprotein Z antibody levels were measured by enzyme-linked immunosorbent assay. Results: The IL-6 levels in preterm delivery patients were elevated during pregnancy with statistically significant differences observed at 21 to 32 weeks ( P < .01) and 33+ weeks ( P < .001). The IL-10 levels were increased in normal pregnancy at all time points compared to the other patient groups ( P < .05). The TNF-α levels were elevated in the high-risk pregnancy group versus normal controls ( P < .001 at Conclusion: Analysis of the maternal plasma for elevated IL-6 and reduced IL-10 levels may be of value in the early prediction of pregnancy complications. |
| Databáze: | OpenAIRE |
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