Relationship between Vitamin D, Parathyroid Hormone, and Bone Health
| Autor: | Adarsh Sai, Xiang Fang, Ryan W. Walters, J. C. Gallagher |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Aging Endocrinology Diabetes and Metabolism Clinical Biochemistry Osteocalcin chemistry.chemical_element Parathyroid hormone Nutritional Status Urine Calcium Biochemistry vitamin D deficiency Bone and Bones Endocrinology Internal medicine medicine Vitamin D and neurology Humans JCEM Online: Hot Topics in Translational Endocrinology Vitamin D Aged Calcium metabolism Sex Characteristics biology Geography business.industry Hydroxycholecalciferols Biochemistry (medical) Liter Reference Standards medicine.disease Vitamin D Deficiency United States Cross-Sectional Studies chemistry Health Parathyroid Hormone biology.protein Linear Models Female business Biomarkers |
| Popis: | There is a controversy regarding the definition of vitamin D insufficiency as it relates to bone health.The objective of the study was to examine the evidence for a threshold value of serum 25-hydroxyvitamin D (25OHD) that defines vitamin D insufficiency as it relates to bone health.This was a cross-sectional analysis of baseline data in 488 elderly Caucasian women, mean age 71 yr, combined with a literature review of 70 studies on the relationship of serum PTH to serum 25OHD.The study was conducted in independent-living women in the midwest United States.The relationship between serum 25OHD, serum PTH, and serum osteocalcin and 24-h urine N-telopeptides was evaluated.Serum PTH was inversely correlated with serum 25OHD (r = -0.256, P0.0005), but no threshold as defined by suppression of serum PTH was found within the serum 25OHD range 6-60 ng/ml (15-150 nmol/liter). However, in contrast, there was a threshold for bone markers, serum osteocalcin and urine N-telopeptides, that increased only below a serum 25OHD of approximately 18 ng/ml (45 nmol/liter). Calcium absorption was not correlated with serum PTH and serum 25OHD, and no threshold was found. A literature review of 70 studies generally showed a threshold for serum PTH with increasing serum 25OHD, but there was no consistency in the threshold level of serum 25OHD that varied from 10 to 50 ng/ml (25-125 nmol/liter).Vitamin D insufficiency should be defined as serum 25OHD less than 20 ng/ml (50 nmol/liter) as it relates to bone. |
| Databáze: | OpenAIRE |
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