Traumatic Brain Injury and Age of Onset of Dementia with Lewy Bodies
| Autor: | Kyle B. Womack, Trung Nguyen, John Hart, J Schaffert, C. Munro Cullum, Christian LoBue |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Lewy Body Disease
Male 0301 basic medicine Pediatrics medicine.medical_specialty Traumatic brain injury Severity of Illness Index Article 03 medical and health sciences 0302 clinical medicine Brain Injuries Traumatic mental disorders Humans Medicine Dementia Age of Onset Risk factor Cognitive decline Aged Aged 80 and over Psychiatric Status Rating Scales business.industry Dementia with Lewy bodies General Neuroscience General Medicine Middle Aged medicine.disease nervous system diseases Psychiatry and Mental health Clinical Psychology 030104 developmental biology nervous system Cohort Female Geriatrics and Gerontology Age of onset business 030217 neurology & neurosurgery Frontotemporal dementia |
| Zdroj: | Journal of Alzheimer's Disease. 66:717-723 |
| ISSN: | 1875-8908 1387-2877 |
| DOI: | 10.3233/jad-180586 |
| Popis: | Background Traumatic brain injury (TBI) with loss of consciousness (LOC) has been associated with earlier onset of mild cognitive impairment, frontotemporal dementia, Parkinson's disease, and Alzheimer's disease (AD), but has not been examined as a risk factor for earlier onset of dementia with Lewy bodies (DLB). Objective The purpose of this study was to assess the association between a history of TBI and the age of onset of DLB. Method Data from 576 subjects with a clinical diagnosis of DLB were obtained from the National Alzheimer's Coordinating Center (NACC). Analyses of Covariance examined whether self-reported history of remote TBI with LOC (i.e., >1 year prior to the first Alzheimer's Disease Center visit) was associated with earlier DLB symptom onset. Results Controlling for sex, those with a history of remote TBI had an approximately 1.5-year earlier clinician-estimated age of onset (F = 0.87, p = 0.35) and 0.75-years earlier age of diagnosis (F = 0.14, p = 0.71) of DLB compared to those without a history of TBI, though the differences did not reach statistical significance. Analysis of subjects with autopsy-confirmed diagnoses was underpowered due to the low number of TBI+ subjects. Conclusions Remote TBI with LOC was not significantly associated with DLB onset, despite being a significant risk factor for cognitive decline and earlier age of onset in other neurodegenerative conditions. Replication of these results using a larger cohort of DLB subjects with and without a TBI history who have undergone autopsy is indicated, as our TBI+ subjects did show a slightly earlier onset of about 1.5 years. Further investigations into other potential DLB risk factors are also warranted. |
| Databáze: | OpenAIRE |
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