Effects of 15-deoxy-Δ12,14-prostaglandin-J2 during hyperdynamic porcine endotoxemia
| Autor: | Zsolt Iványi, Jochen Kick, Claus-Martin Muth, Ulrich Ehrmann, Michael Bauer, Balázs Hauser, Maura Albicini, Peter Radermacher, Josef Vogt, Uwe B. Brückner, Hendrik Bracht, Ulrich Wachter, Pierre Asfar |
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| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
Mean arterial pressure Swine Hemodynamics Prostaglandin Cyclopentanes Critical Care and Intensive Care Medicine Proinflammatory cytokine Nitric oxide Random Allocation chemistry.chemical_compound Internal medicine Intensive care medicine Animals Immunologic Factors Prospective Studies Prostaglandin D2 business.industry Respiration Artificial Endotoxemia Europe Oxidative Stress Endocrinology Blood pressure chemistry Eicosanoid Prostaglandins Hypotension business |
| Zdroj: | Intensive Care Medicine. 32:759-765 |
| ISSN: | 1432-1238 0342-4642 |
| DOI: | 10.1007/s00134-006-0107-8 |
| Popis: | To investigate the hemodynamic and metabolic effects of the peroxisome proliferator-activated receptor (PPAR)-gamma ligand and nuclear-factor (NF)-kappa B inhibitor 15-deoxy-Delta12,14-prostaglandin-J2 (15d-PGJ2) during long-term, hyperdynamic porcine endotoxemia.Prospective, randomized, controlled experimental study with repeated measures.Investigational animal laboratory.19 anesthetized, mechanically ventilated and instrumented pigs.At 12 h of continuous intravenous endotoxin and hydroxyethylstarch to keep mean arterial pressure (MAP)60 mmHg, swine randomly received vehicle (control group, n=10) or 15-deoxy-Delta12,14-prostaglandin-J2 (15d-PGJ2 group, n=9; 1 microg kg(-1) min(-1) loading dose during 1 h; thereafter,0.25 microg kg(-1) min(-1) for 11 h).Hemodynamic, metabolic and organ function parameters were assessed together with parameters of nitric oxide production and oxidative stress. 15d-PGJ2 prevented the endotoxin-induced progressive hypotension, due to a positive inotropic effect, which resulted in a significantly higher blood pressure during the treatment phase and prevented the rise in hepatic vein alanine-aminotransferase activity. It did not affect, however, any other parameter of organ function nor of nitric oxide production, proinflammatory cytokine release or lipid peroxidation (8-isoprostane).15d-PGJ2 stabilized systemic hemodynamics, due to improved myocardial performance, and resulted in an only transient effect on alanine-aminotransferase activity, without further beneficial effect on endotoxin-induced metabolic and organ function derangements. Low tissue 15d-PGJ2 concentrations and/or the delayed drug administration may explain these findings. |
| Databáze: | OpenAIRE |
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