Endocytoscopy in Esophageal Cancer
| Autor: | Ganapathy A. Prasad, Louis M. Wong Kee Song, Hamza M. Abdulla, Yutaka Tomizawa, Lynn S. Borkenhagen, Kenneth K. Wang, Lori S. Lutzke |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Oncology
medicine.medical_specialty Esophageal Neoplasms Biopsy medicine.medical_treatment Magnification Endoscopic mucosal resection Adenocarcinoma Sensitivity and Specificity Article Diagnosis Differential Barrett Esophagus Esophagus Internal medicine medicine Humans Cell Nucleus Extramural business.industry Gastroenterology Esophageal cancer medicine.disease Esophagectomy medicine.anatomical_structure Barrett's esophagus Gastroesophageal Reflux Esophagoscopy Radiology business Precancerous Conditions |
| Zdroj: | Gastrointestinal Endoscopy Clinics of North America. 19:273-281 |
| ISSN: | 1052-5157 |
| DOI: | 10.1016/j.giec.2009.02.006 |
| Popis: | The ability to visualize in vivo microscopic areas of neoplasia within gastrointestinal mucosa has been a major quest of modern gastroenterology. The attainment of this goal could revolutionize the diagnosis and treatment of neoplastic disease. Potential benefits could include the elimination of random biopsies for surveillance of mucosal disease and increasing time intervals between surveillance endoscopy, elimination of sampling error issues, decrease inter-procedural discrepancies regarding the presence and magnitude of dysplasia present and ultimately to improve patient outcomes with at risk neoplasia. Recent advances in endocytoscopy can help guide the early detection of malignancy and lead to earlier treatment. Endocytoscopy is a new imaging and magnification technology classified as one of the “contact devices”, has been developed for observation of cellular structure in vivo with particular application in the esophagus. The technology can provide accurate targeting of lesions with an in vivo “virtual histological diagnosis” and could enhance endoscopic surveillance by decreasing biopsies of normal appearing mucosa. The purpose of this review is to survey the technology available and examine the literature to date regarding its clinical usage. We will also conclude this review with potential future directions. |
| Databáze: | OpenAIRE |
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