Clinicopathologic Characteristics and Survival Outcomes in Floor of Mouth Squamous Cell Carcinoma: A Population‐Based Study
| Autor: | Edward C. Kuan, Albert Y Han, Karam W. Badran, Maie A. St. John, Satvir Saggi |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine Oncology medicine.medical_specialty Multivariate analysis Adolescent medicine.medical_treatment Cohort Studies Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine Epidemiology Humans Medicine Stage (cooking) Mouth Floor Aged Retrospective Studies Aged 80 and over Floor of mouth business.industry Head and neck cancer Retrospective cohort study Middle Aged medicine.disease United States Survival Rate Radiation therapy 030104 developmental biology Otorhinolaryngology 030220 oncology & carcinogenesis Cohort Carcinoma Squamous Cell Female Mouth Neoplasms Surgery business SEER Program |
| Zdroj: | Otolaryngology–Head and Neck Surgery. 159:51-58 |
| ISSN: | 1097-6817 0194-5998 |
| DOI: | 10.1177/0194599818756815 |
| Popis: | Objective To describe the determinants of survival for patients with floor of mouth (FOM) squamous cell carcinoma (SCC) from 1973 to 2013 with the SEER database (Surveillance, Epidemiology, and End Results). Study Design and Setting Retrospective cohort study with a national database. Subjects and Methods The SEER registry was utilized to calculate survival trends for patients with FOM SCC between 1973 and 2013. Patient data were analyzed with respect to age, sex, race, primary site, stage at presentation, tumor size, grade, and treatment modalities (surgery and radiotherapy). Overall survival (OS) and disease-specific survival (DSS) were calculated. Results A total of 14,010 FOM SCC cases were identified. The cohort was 69.5% male, and the median age at diagnosis was 62 years. Forty-six percent of cases were treated with surgery, while 14% received radiotherapy. Kaplan-Meier analysis demonstrated OS and DSS of 39% and 59% at 5 years, respectively. Multivariate analysis showed that age, grade, stage, size, and surgery were determinants for OS and DSS (all P < .05). For early- and advanced-stage cancers, age, grade, size, and surgery predicted OS and DSS, while radiotherapy was a predictor of OS and DSS in advanced-stage tumors only (all P < .05). Conclusion To our knowledge, this study is the largest to date investigating prognostic factors for survival of patients diagnosed with FOM SCC. Determinants of survival include age, grade, stage, size, and surgery. Surgery appears to play a critical role in the management of these tumors. |
| Databáze: | OpenAIRE |
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